组织工程骨移植物的血管化策略研究  

Research on vascularization strategy of bone tissue engineering graft

作　　者：张一帆 张郭 汪振星 孙家明[1] ZHANG Yifan;ZHANG Guo;WANG Zhenxing;SUN Jiaming(Department of Plastic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院整形外科,湖北省武汉市430022

出　　处：《组织工程与重建外科》2024年第2期234-239,264,共7页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：利用骨组织工程修复大段骨缺损是一种富有前景的方法。骨骼是动态的高度血管化组织,在适当时间内形成血管组织是保证骨移植物存活、修复、重塑的关键,也是骨组织工程的主要挑战之一。本文将从血管化的意义,以及基于种子细胞、促血管生成因子、支架结构、免疫调控、体外预血管化等策略来综述组织工程骨移植物血管化的研究进展。Bone tissue engineering is a promising method for repairing large-scale bone defects.Bone is a dynamic and highly vascularized tissue,and the formation of vascular tissue in an appropriate time is the key to ensure the survival,repair and remodeling of bone graft,as well as one of the main challenges of bone tissue engineering.In this paper,the research progress of vascularization of bone tissue engineering grafts from the perspective of the significance of vascularization and strategies based on seed cells,angiogenic factors,scaffold structure,immune regulation,and prevascularization was reviewed.

关 键 词：组织工程 大段骨缺损 移植物 血管化 骨修复 

分 类 号：R318.1[医药卫生—生物医学工程]