A multi-functional MgF_(2)/polydopamine/hyaluronan-astaxanthin coating on the biodegradable ZE21B alloy with better corrosion resistance and biocompatibility for cardiovascular application  

作　　者：Yachen Hou Xueqi Zhang Jingan Li Liguo Wang Shaokang Guan 

机构地区：[1]School of Materials Science and Engineering and Henan Key Laboratory of Advanced Magnesium Alloy and Key Laboratory of Materials Processing and Mold Technology(Ministry of Education),Zhengzhou University,Zhengzhou 450001,China

出　　处：《Journal of Magnesium and Alloys》2024年第3期1102-1116,共15页镁合金学报（英文）

基　　金：For financial support,the authors gratefully acknowledge the National Natural Science Foundation of China(U2004164);the National Key Research and Development Program of China(2018YFC1106703);the Key Projects of the Joint Fund of the National Natural Science Foundation of China(U1804251).

摘　　要：The cardiovascular diseases(CVD)continue to be the major threat to global public health over the years,while one of the effective methods to treat CVD is stent intervention.Biomedical magnesium(Mg)alloys have great potential applications in cardiovascular stents benefit from their excellent biodegradability and absorbability.However,excessive degradation rate and the delayed surface endothelialization still limit their further application.In this study,we modified a Mg-Zn-Y-Nd alloy(ZE21B)by preparing MgF_(2) as the corrosion resistance layer,the dopamine polymer film(PDA)as the bonding layer,and hyaluronic acid(HA)loaded astaxanthin(ASTA)as an important layer to directing the cardiovascular cells fate.The electrochemical test results showed that the MgF_(2)/PDA/HA-ASTA coating improved the corrosion resistance of ZE21B.The cytocompatibility experiments also demonstrated that this novel composite coating also selectively promoted endothelial cells proliferation,inhibited hyperproliferation of smooth muscle cells and adhesion of macrophages.Compared with the HAloaded rapamycin(RAPA)coating,our MgF_(2)/PDA/HA-ASTA coating showed better blood compatibility and cytocompatibility,indicating stronger multi-functions for the ZE21B alloy on cardiovascular application.

关 键 词：Biodegradable ZE21B alloy REENDOTHELIALIZATION Surface modification Hyaluronic acid Astaxanthin. 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.4[医药卫生—基础医学]