5例直接口服抗凝药治疗非瓣膜性房颤患者左心耳血栓的用药分析  

Analysis of 5 Cases of Direct Oral Anticoagulants in the Treatment of Left Atrial Appendage Thrombosis in Patients with Nonvalvular Atrial Fibrillation

作　　者：侯凯 费禹翔 李平[1] 张金莲[1] 王芳[1] 杨宇[1] HOU Kai;FEI Yuxiang;LI Ping;ZHANG Jinlian;WANG Fang;YANG Yu(Department of Clinical Pharmacy,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200092,China;Department of Pharmacy,Zhongda Hospital,Southeast University,Nanjing 210009,China;Department of Pharmacy,Nanjing First Hospital,Nanjing 210006,China)

机构地区：[1]上海交通大学医学院附属新华医院临床药学部,上海200092 [2]东南大学附属中大医院药学部,南京210009 [3]南京市第一医院药学部,南京210006

出　　处：《药学与临床研究》2024年第2期165-168,共4页Pharmaceutical and Clinical Research

基　　金：国家自然科学基金-青年科学基金项目(82204394);南京药学会常州四药医院药学科研基金项目(2022YX003)。

摘　　要：临床药师参与5例非瓣膜性房颤合并左心耳血栓患者的抗凝治疗管理,通过患者临床表现、食道超声心动图评估药物的安全性与疗效,分析利伐沙班和艾多沙班对于协助纤溶系统溶解左心耳血栓的效果与差异。结果显示两种药物均能不同程度地促进血栓消退,血栓消退的时间可能与血栓面积以及患者心功能相关。术后临床药师结合患者肾功能与合并用药情况,为患者制定安全、有效、个体化的抗凝方案。Clinical pharmacists participated in the management of anticoagulant therapy for 5 patients with nonvalvular atrial fibrillation combined with left atrial appendage thrombus.The safety and efficacy of drugs were evaluated by clinical manifestations and esophageal echocardiography.The efficacy and difference of rivaroxaban and edoxaban in assisting fibrinolytic system to dissolve left atrial appendage thrombus were analyzed.The results showed that both drugs could promote the thrombus resolution to varying degrees,and the time of thrombus resolution may be related to the thrombus area and the heart function of patients.After operation,clinical pharmacists formulated safe,effective and individualized anticoagulation regimens for patients according to their renal function and combined medications.

关 键 词：临床药师 非瓣膜性房颤 左心耳血栓 利伐沙班 艾多沙班 

分 类 号：R972[医药卫生—药品]