炎症细胞因子与阻塞性睡眠呼吸暂停的相互作用研究进展  

Research progress on the interaction between inflammatory cytokines and obstructive sleep apnea

作　　者：李东阳 郭澳 马文彬[1] LI Dongyang;GUO Ao;MA Wenbin(Department of Neurology,Binzhou Medical University Hospital,Shandong 256600,China)

机构地区：[1]滨州医学院附属医院神经内科,山东256600

出　　处：《中国临床新医学》2024年第4期476-480,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：山东省医药卫生科技发展计划项目(编号:2019WS328)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠相关呼吸系统疾病。慢性间歇性缺氧可以导致机体的炎症反应,激活各种炎症通路,加重OSA。炎症细胞因子是一类细胞信号分子,它通过自分泌、旁分泌和内分泌等方式进行信息传递。OSA和全身炎症以及炎症细胞因子之间联系密切,肿瘤坏死因子-α、白细胞介素(IL)-33、IL-17、IL-10、IL-1β、IL-6和IL-8等炎症细胞因子被证实参与了OSA的发病过程,并促进炎症通路的再激活。该文对炎症细胞因子与OSA发生、发展的研究进展作一综述。Obstructive sleep apnea(OSA)is a common sleep-related respiratory disorder.Chronic intermittent hypoxia can lead to inflammatory response in the body,activate various inflammatory pathways and aggravate OSA.Inflammatory cytokines are a class of cellular signaling molecules,which transmit information by means of autocrine,paracrine and endocrine.OSA is closely associated with systemic inflammation and inflammatory cytokines.Inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-33,IL-17,IL-10,IL-1β,IL-6 and IL-8,have been proven to participate in the pathogenesis of OSA and promote the reactivation of inflammatory pathways.In this paper,the research progress on inflammatory cytokines and the occurrence and development of OSA is reviewed.

关 键 词：阻塞性睡眠呼吸暂停 炎症细胞因子 肿瘤坏死因子-Α 白细胞介素 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]