基于液体射流破碎法制备粒径可控的聚乙烯醇微球  

A method for preparing polyvinyl alcohol microspheres with controllable particle size based on liquid jet breakup

作　　者：赵培 许珂 吴迪 黄琳静 杨志强 邹方明 赵成如 夏毅然 ZHAO Pei;XU Ke;WU Di;HUANG Linjing;YANG Zhiqiang;ZOU Fangming;ZHAO Chengru;XIA Yiran(Success Bio-Tech Co.,Ltd.,Jinan 250101,China;Biomedical Materials Engineering Research Center of Shandong Province,Jinan 250101)

机构地区：[1]赛克赛斯生物科技股份有限公司,济南250101 [2]生物医用材料山东省工程研究中心,济南250101

出　　处：《生物医学工程研究》2024年第2期159-165,共7页Journal Of Biomedical Engineering Research

基　　金：济南市科技计划(后补助)项目(202131015)。

摘　　要：在工业生产中,聚乙烯醇(polyvinyl alcohol,PVA)微球多采用机械搅拌法制备,得到的微球粒径不可控、粒径分布宽、小粒径(100~300μm)微球产率低。为改善上述问题,本研究将液体射流破碎法应用于油包水(W/O)微球制备体系,制备了粒径可控、粒径分布窄的PVA水凝胶微球。本研究系统研究了分散相流速、PVA浓度、加料装置内径及稳定剂浓度对微球粒径和粒径分布的影响。最终,采用分散相流速为40 mL/min、PVA浓度为7.0%、加料装置内径为400μm及稳定剂浓度为11.5%的条件,制备了平均粒径为146.00μm,粒径分布为1.63的PVA微球。该方法得到的小粒径微球产率高、批次间重复性良好、装置简单,可实现微球的规模化生产。In the industrial production,polyvinyl alcohol(PVA)microspheres are mostly prepared by mechanical stirring method,resulting in uncontrollable particle size,wide particle size distribution and low yield of small particle size(100~300μm)microspheres.To improve these issues,PVA hydrogel microspheres with controlled particle size was prepared by liquid jet breakup method.The processing conditions,dispersed phase flow rate,PVA concentration,diameter of the feeding device and the stabilizer concentration were optimized to fabricate PVA microspheres.Finally,the PVA microspheres with an average particle size of 146.00μm and size distribution coefficient of 1.63 were successfully fabricated by using 400μm feeding device under the dispersed phase flow rate of 40 mL/min,the dispersed phase concentration of 7.0%,and the stabilizer concentration of 11.5%.This method improves the yield of small particle size microspheres,has good repeatability between batches,which can realize large-scale production of microspheres.

关 键 词：介入栓塞 液体射流破碎法 聚乙烯醇微球 加料装置 粒径分布 

分 类 号：R318[医药卫生—生物医学工程]