贝那鲁肽与四联活菌制剂结合治疗肥胖型2型糖尿病患者的效果  

Effect of Benalutide Combined with Tetraceutide in the Treatment of Obese Patients with Type 2 Diabetes Mellitus

作　　者：杨凡 马晓君[1] 李志臻[1] 张会娟[1] 秦贵军[1] YANG Fan;MA Xiaojun;LI Zhizhen;ZHANG Huijuan;QIN Guijun(Department of Endocrinology and Metabolism,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院内分泌与代谢病科,河南郑州450000

出　　处：《河南医学研究》2024年第9期1678-1682,共5页Henan Medical Research

摘　　要：目的分析四联活菌制剂联合贝那鲁肽在肥胖型2型糖尿病(T2DM)中的应用价值。方法以随机数字表法将医院2022年1月至2023年1月接收的104例肥胖型T2DM患者分为对照组、研究组,各52例。对照组接受贝那鲁肽治疗,研究组接受贝那鲁肽联合四联活菌制剂治疗。比较两组疗效、不良反应、治疗前后血糖指标[餐后2 h血糖(2 h PG)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)]、胰岛素抵抗指数(HOMA-IR)、体脂相关指标[空腹C肽(FCP)、瘦素(LEP)、爱帕琳肽13、腹内脂肪含量]、肠道菌群及炎症相关指标[分泌型卷曲相关蛋白-5(SFRP-5)、单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子α(TNF-α)、蛋白络氨酸磷酸酶-1 B(PTP-1B)]。结果研究组总有效率(96.15%)高于对照组(82.69%)(P<0.05);治疗后研究组2 h PG、FBG、HbA1c、HOMA-IR、LEP、腹内脂肪含量、MCP-1、TNF-α、PTP-1B均低于对照组,FCP、爱帕琳肽13、SFRP-5均高于对照组(P<0.05);治疗后研究组双歧杆菌、乳杆菌数量较对照组高,酵母菌、肠球菌数量较对照组低(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论四联活菌制剂联合贝那鲁肽治疗肥胖型T2DM的效果确切,可促进肠道菌群、血糖水平、体脂相关指标改善,减轻机体炎症,促进病情恢复。Objective To analyze the application value of tetraceutide combined with benalutide in the treatment of obese type 2 diabetes mellitus(T2DM).Methods A total of 104 obese T2DM patients admitted to the hospital from January 2022 to January 2023 were divided into control group and study group,with 52 cases in each group.The control group was treated with benalutide,and the study group was treated with beinaglutide combined with tetraceutide.The efficacy,adverse reactions and blood glucose indexes before and after treatment[2-hour postprandial blood glucose(2 h PG),fasting blood glucose(FBG),hemoglobin A1c(HbA1c)],homeostasis model assessment-insulin resistance(HOMA-IR),body fat related indicators[fasting C-peptide(FCP),leptin(LEP),apelin-13,abdominal fat content],intestinal flora and inflammation related indicators[secreted frizzled related protein(SFRP-5),monocyte chemoattractant protein 1(MCP-1),tumor necrosis factorα(TNF-α),protein tyrosine phosphatase-1b(PTP-1B)]were compared between the two groups.Results The total effective rate of the study group(96.15%)was higher than that of the control group(82.69%)(P<0.05).After treatment,2 h PG,FBG,HbA1c,HOMA-IR,LEP,intra-abdominal fat contents,MCP-1 and TNF-αand PTP-1B in study group were lower than those in control group,and FCP,apelin-13 and SFRP-5 in study group were higher than those in control group(P<0.05).After treatment,Bifidobacterium and Lactobacillus in study group were higher than those in control group,and Yeast and Enterococcus were lower than those in control group(P<0.05).There was no stastistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of obese T2DM with the combination of tetraceutide with benalutide is effective,which can promote the improvement of intestinal flora,blood sugar level,body fat related indexes,reduce inflammation,and promote the recovery of the disease.

关 键 词：四联活菌 贝那鲁肽 2型糖尿病 疗效 

分 类 号：R587.1[医药卫生—内分泌]