冰玄涂膜剂的制备及体外透皮研究  

Study on the preparation and in vitro transdermal of Bingxuan Paints

作　　者：陈佳丽 陈欣欣 马月光[1] CHEN Jiali;CHEN Xinxin;MA Yueguang(Traditional Chinese Medicine Pharmacy,Hangzhou First People’s Hospital,Zhejiang Province,Hangzhou310006,China;College of Pharmacy,Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou311403,China)

机构地区：[1]杭州市第一人民医院中药房,浙江杭州310006 [2]浙江中医药大学药学院,浙江杭州311403

出　　处：《中国医药导报》2024年第8期7-12,共6页China Medical Herald

基　　金：浙江省杭州市医药卫生科技项目(A20210293、ZD20210037);浙江省中医药科技计划项目(2022ZB272)。

摘　　要：目的 优选冰玄涂膜剂处方组成并研究其体外透皮特性。方法 采用单因素实验结合响应面法,以溶剂含醇量、成膜材料、增塑剂为考察因素,成膜时间、成膜性、均匀度等作为评价指标,优选冰玄涂膜剂的处方组成;采用Franz扩散池考察其体外透皮特性。结果 60%溶剂含醇量,10%PVA-124(成膜材料)、3%邻苯二甲酸二丁酯(增塑剂)是冰玄涂膜剂最优处方组成。且该条件下制得的冰玄涂膜剂36 h后累计渗透量为1 536.62μg/cm^(2),渗透率为256.47μg/(cm^(2)·h)。结论 经优选的冰玄涂膜剂处方成剂稳定可靠,且透皮效果更佳。Objective To optimize the formulation of Bingxuan Paints and to study its in vitro transdermal characteristics.Methods The single factor experiment combined with response surface method was used to optimize the formulation of Bingxuan Paints with alcohol content of solvent,film forming material,and plasticizer as the factors,film forming time,film forming property,and uniformity as the evaluation indexes;the in vitro transdermal characteristics were investigated by Franz diffusion cell.Results The optimum formulation of Bingxuan Paints consisted of 60%alcohol content of solvent,10%of PVA-124(film forming material),and 3%of dibutyl phthalate(plasticizer).The cumulative permeability and permeability of the film prepared under these conditions were 1536.62μg/cm^(2) and 256.47μg/(cm^(2)·h)after 36 h.Conclusion The optimization Bingxuan Paints stable and reliable,and has better transdermal effect.

关 键 词：玄明粉 冰片 涂膜剂 处方优化 体外透皮 

分 类 号：R283.6[医药卫生—中药学]