先天性巨结肠肠道微生态平衡维持措施的研究进展  

Research progress intestinal microecological balance maintenance measures in congenital megacolon

作　　者：王国辉[1] 王赞 张书景 牛波波 邢扩 牛会忠[1] WANG Guohui;WANG Zan;ZHANG Shujing;NIU Bobo;XING Kuo;NIU Huizhong(The First Department of General Surgery,Hebei Children’s Hospital,Hebei Province,Shijiazhuang050031,China;Yuhua District Maternal and Child Health and Family Planning Service Center,Hebei Province,Shijiazhuang050030,China)

机构地区：[1]河北省儿童医院普外一科,河北石家庄050031 [2]石家庄市裕华区妇幼保健计划生育服务中心,河北石家庄050030

出　　处：《中国医药导报》2024年第8期44-47,共4页China Medical Herald

基　　金：河北省卫生健康委员会医学科学研究课题计划项目(20231145)。

摘　　要：先天性巨结肠是肠神经系统发育障碍、肠神经节细胞缺如引起功能性肠动力紊乱的疾病,是小儿外科常见的先天性消化道畸形疾病,其主要特征是病变肠管肌间和黏膜下神经丛内神经节细胞的缺乏引起病变肠管的痉挛。主要治疗方式为手术切除无神经节细胞肠管。针对先天性巨结肠患儿存在肠道免疫功能缺陷,容易引起细菌易位导致感染的特点,本文就营养状态、微生态制剂、扩肛、结肠灌洗、手术方式等方面对先天性巨结肠患儿肠道菌群的影响进行阐述,以加强临床医师对先天性巨结肠的认识,提高治疗效果。Congenital megacolon is a functional intestinal motility disorder caused by developmental disorders of the intestinal nervous system and the absence of intestinal ganglion cells.It is a common congenital digestive tract malformation in pediatric surgery.Its main feature is the spasm caused by the absence of ganglion cells in the intramuscular and submucosal nerve plexus.The main treatment is surgical resection of the non-ganglionic intestinal tube.According to the characteristics of intestinal immune function deficiency in children with congenital megacolon,which is easy to cause bacterial translocation and infection,this paper expounds the effects of nutritional status,microecological preparations,anal dilatation,colon irrigation,and surgical methods on the intestinal flora of children with congenital megacolon,so as to strengthen clinicians’understanding of congenital megacolon and improve the therapeutic effect.

关 键 词：先天性巨结肠 细菌易位 微生态制剂 扩肛 

分 类 号：R720.5[医药卫生—儿科]