血清脑钠肽、心肌肌钙蛋白T及休克指数与急性心肌梗死患者经皮冠脉介入术后主要不良心血管事件的相关性分析  

Correlation analysis of serum brain natriuretic peptide,cardiac troponin T,and shock index with major adverse cardiovascular events in patients with acute myocardial infarction after percutaneous coronary intervention

作　　者：胡夏兵 刘爱军[2] 张永林[2] 钱文浩 HU Xiabing;LIU Aijun;ZHANG Yonglin;QIAN Wenhao(Department of Cardiovascular Medicine,the Affiliated Hospital of Xuzhou Medical University,Jiangsu Province,Xuzhou 221000,China;Department of Cardiovascular Medicine,Binhai County People’s Hospital,Jiangsu Province,Binhai 300459,China)

机构地区：[1]徐州医科大学附属医院心血管内科,江苏徐州221000 [2]江苏省滨海县人民医院心血管内科,江苏滨海300459

出　　处：《中国医药导报》2024年第8期82-85,98,共5页China Medical Herald

基　　金：江苏省研究生科研与实践创新计划项目基金资助项目(SJCX21_1148)。

摘　　要：目的 探讨血清脑钠肽(BNP)、心肌肌钙蛋白T(c Tn T)及休克指数(SI)与急性心肌梗死(AMI)患者经皮冠脉介入术(PCI)后主要不良心血管事件(MACE)的相关性。方法 回顾性分析2017年11月至2022年11月于徐州医科大学附属医院、江苏省滨海县人民医院进行PCI治疗的200例AMI患者的临床资料,将其分为MACE组(60例)与无MACE组(140例)。比较两组基线资料、血管狭窄程度(Gensini)评分、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及术前白蛋白、BNP、c Tn T、SI。采用logistic逐步回归分析MACE的危险因素,通过受试者工作特征(ROC)曲线分析各指标预测MACE的价值。结果 MACE组糖尿病患者占比及年龄、BNP、c Tn T、SI水平高于无MACE组(P<0.05)。logistic逐步回归分析结果显示,年龄(OR=2.145,95%CI=1.056~4.357)、BNP (OR=1.985,95%CI=1.156~3.408)、c Tn T (OR=1.997,95%CI=1.145~3.483)、SI(OR=1.897,95%CI=1.260~3.196)是AMI患者PCI治疗后MACE发生的危险因素(P<0.05)。ROC曲线分析结果显示,年龄、BNP、c Tn T、SI均可用于预测AMI患者PCI治疗后MACE的发生(P<0.05)。结论 年龄、BNP、c Tn T、SI可影响AMI患者PCI治疗后MACE的发生,可用于预测MACE的发生。Objective To explore the correlation of serum brain natriuretic peptide(BNP),cardiac troponin T(cTnT),shock index(SI),and major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)treatment in patients with acute myocardial infarction(AMI).Methods Clinical data of 200 AMI patients treated with PCI at the Affiliated Hospital of Xuzhou Medical University and Binhai County People’s Hospital in Jiangsu Province from November 2017 to November,2022 was retrospectively analyzed,and they were divided into MACE group(60 cases)and non-MACE group(140 cases).Baseline data,degree of vascular stenosis(Gensini)score,total cholesterol(TC),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),preoperative albumin,BNP,cTnT,and SI were compared between two groups.Risk factors of MACE were analyzed by logistic stepwise regression,and receiver operator characteristic(ROC)curve analysis was used to analyze the predictive value of various indicators in MACE.Results The proportion of patients with diabetes,age,and the levels of BNP,cTnT,and SI in the MACE group were higher than those in the non-MACE group(P<0.05).Logistic stepwise regression analysis results showed that,age(OR=2.145,95%CI=1.056-4.357),BNP(OR=1.985,95%CI=1.156-3.408),cTnT(OR=1.997,95%CI=1.145-3.483),and SI(OR=1.897,95%CI=1.260-3.196)were the risk factors for MACE in AMI patients after PCI treatment.ROC curve analysis results showed that,age,diabetes,cTnT,and SI could be used to predict the occurrence of MACE in AMI patients after PCI treatment(P<0.05).Conclusion The occurrence of MACE in AMI patients after PCI treatment is influenced by age,BNP,cTnT,and SI,which can be used to predict the occurrence of MACE.

关 键 词：脑钠肽 心肌肌钙蛋白T 休克指数 急性心肌梗死 经皮冠脉介入术 主要不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]