内皮抑素对青壮年Garden Ⅲ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合的影响  

Effect of endostatin on delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults

作　　者：姚有榕 王刚[1] 舒振云[2] 罗正理 魏强强 YAO Yourong;WANG Gang;SHU Zhenyun;LUO Zhengli;WEI Qiangqiang(Ward Four,Department of Orthopedics,the 72nd Group Military Hospital of the Chinese People’s Liberation Army,Zhejiang Province,Huzhou313000,China;Department of Emergency,the 72nd Group Military Hospital of the Chinese People’s Liberation Army,Zhejiang Province,Huzhou313000,China)

机构地区：[1]中国人民解放军陆军第七十二集团军医院骨科四病区,浙江湖州313000 [2]中国人民解放军陆军第七十二集团军医院急诊科,浙江湖州313000

出　　处：《中国医药导报》2024年第9期95-98,共4页China Medical Herald

基　　金：浙江省医药卫生科技计划项目(2019KY682)。

摘　　要：目的 探讨内皮抑素对青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合的影响。方法 回顾性收集2020年1月至2023年1月中国人民解放军陆军第七十二集团军医院107例青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术患者的临床资料,依据术后是否发生延迟愈合将其分为对照组与延迟组。比较两组临床资料;分析青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合的影响因素;绘制受试者操作特征(ROC)曲线,评估内皮抑素对青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合的预测价值。结果 107例患者术后延迟愈合发生率为12.15%(13/107)。延迟组血管内皮生长因子(VEGF)、骨特异性碱性磷酸酶(BALP)水平低于对照组,内皮抑素水平高于对照组(P<0.05)。内皮抑素为青壮年GardenⅢ~Ⅳ型股骨颈骨折术后延迟愈合的危险因素(OR=1.067,P<0.05),VEGF、BALP为保护因素(OR=0.942、0.762,P<0.05)。内皮抑素预测青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合的曲线下面积为0.828。结论 内皮抑素可影响青壮年GardenⅢ~Ⅳ型股骨颈骨折切开复位内固定术后延迟愈合,可将其作为预测患者术后延迟愈合的潜在指标。Objective To investigate the effect of endostatin on delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults.Methods The clinical data of 107 young adults with Garden typeⅢ-Ⅳfemoral neck fractures underwent open reduction and internal fixation surgery in the 72nd Group Military Hospital of the Chinese People’s Liberation Army from January 2020 to January 2023 were retrospectively collected.According to whether delayed healing occurred after surgery,they were divided into control group and delayed group.The clinical data of two groups were compared;and the influencing factors of delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults were analyzed;receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of endostatin in delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults.Results The incidence of delayed healing was 12.15%(13/107)in 107 patients.The levels of vascular endothelial growth factor(VEGF)and bone-specific alkaline phosphatase(BALP)in delayed group were lower than those in control group,and the level of endostatin was higher than that in control group(P<0.05).Endostatin was the risk factor for delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fracture in young adults(OR=1.067,P<0.05),VEGF and BALP were the protective factors(OR=0.942,0.762,P<0.05).The area under the curve of endostatin in predicting delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults was 0.828.Conclusion Endostatin can affect delayed healing after open reduction and internal fixation surgery of Garden typeⅢ-Ⅳfemoral neck fractures in young adults,and can be used as a potential indicator to predict delayed healing.

关 键 词：股骨颈骨折 青壮年 切开复位内固定术 内皮抑素 延迟愈合 

分 类 号：R683.42[医药卫生—骨科学]