一种新型氧合器的设计、数值仿真与实验研究  

Design, numerical simulation and experimental study of novel oxygenator

作　　者：岳明昊 张世耀 李纪念 刘会超 苏子华 王亚伟 陈增胜[2] 林世航 李晋渝 成雅科 胡永飞 贾存鼎 徐明洲 YUE Ming-hao;ZHANG Shi-yao;LI Ji-nian;LIU Hui-chao;SU Zi-hua;WANG Ya-wei;CHEN Zeng-sheng;LIN Shi-hang;LI Jin-yu;CHENG Ya-ke;HU Yong-fei;JIA Cun-ding;XU Ming-zhou(Beijing Aerospace Changfeng Co.,Ltd.,Beijing 100039,China;BEIHANG UNIVERSITY,Beijing 100191,China)

机构地区：[1]北京航天长峰股份有限公司,北京100039 [2]北京航空航天大学,北京100191

出　　处：《医疗卫生装备》2024年第3期23-28,共6页Chinese Medical Equipment Journal

基　　金：国家重点研发计划项目(2020YFC0862900,2020YFC0862902)。

摘　　要：目的:设计一种新型氧合器,以解决目前体外膜肺氧合设备存在的跨膜压差大、血氧交换效率低、易发血栓等问题。方法:首先,将氧合器血液通路流场主体设置为扁平圆柱体。其次,对血液通路拓扑结构进行三维建模,并将整个流场切分为血液入口段及入口缓冲区、热交换区、血氧交换区、出口缓冲区及血液出口段。最后,采用ANSYS FLUENT软件进行仿真分析和样机制作实验,对比设计的氧合器和Quadrox氧合器的性能。结果:仿真计算表明,设计的氧合器整体性能与临床常用氧合器处于同等水平,且在跨膜压差、血氧交换和流量均匀性方面更优。实验结果表明,设计的氧合器跨膜压差和血氧交换率优于Quadrox氧合器。结论:设计的氧合器跨膜压差小、变温效果好、血氧交换效率高、血栓发生概率低,具有一定的优越性。Objective To design a novel oxygenator to solve the existing problems of extracorporeal membrane oxygenation(ECMO)machine in high transmembrane pressure difference,low efficiency of blood oxygen exchange and susceptibility to thrombosis.Methods The main body of the oxygenator vascular access flow field was gifted with a flat cylindrical shape.The topology of the vascular access was modeled in three dimensions,and the whole flow field was cut into a blood inlet section,an inlet buffer,a heat exchange zone,a blood oxygen exchange zone,an outlet buffer and a blood outlet section.The oxygenator was compared with Quadrox oxygenator by means of ANSYS FLUENT-based simulation and prototype experiments.Results Simulation calculations showed the oxygenator designed was comparable to the clinically used ones in general,and gained advantages in transmembrane pressure difference,blood oxygen exchange and flow uniformity.Experimental results indicated that the oxygenator behaved better than Quadrox oxygenator in transmembrane pressure difference and blood oxygen exchange.Conclusion The oxygenator has advantages in transmem-brane pressure difference,temperature change,blood oxygen ex-change and low probability of thrombosis.

关 键 词：体外膜肺氧合 氧合器 血液通路 数值仿真 

分 类 号：R318.6[医药卫生—生物医学工程] TH772.1[医药卫生—基础医学]