补肾活血汤联合环磷酰胺治疗难治性肾病综合征临床研究  

作　　者：高明 李科萌 赵艳玲 

机构地区：[1]河南省驻马店市第一人民医院肾病科,河南驻马店463000

出　　处：《实用中医药杂志》2024年第4期661-663,共3页Journal of Practical Traditional Chinese Medicine

摘　　要：目的:观察补肾活血汤联合环磷酰胺治疗难治性肾病综合征的临床疗效。方法:78例随机分为对照组37例和观察组41例,两组均用环磷酰胺治疗,观察组加用补肾活血汤治疗。结果:观察组总有效率高于对照组(P<0.05)。治疗后两组面浮肢肿、畏寒怕冷及腰膝酸痛积分均低于治疗前,且观察组低于对照组(P<0.05)。治疗后两组BUN、Scr水平均下降,且观察组下降幅度大于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:补肾活血汤联合环磷酰胺治疗难治性肾病综合征疗效较好,且安全。Objective:To observe the clinical efficacy of Kidney-tonifying and Blood-activating Decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome.Methods:Seven-eight cases were randomly divided into the control group(37 cases)and the observation group(41 cases).The two groups were treated with cyclophosphamide,and the observation group were treated with Bushen Huoxue Decoction in addition.Results:The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the scores of facial edema,aversion to cold,and soreness of the waist and knee in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After treatment,the levels of BUN and Scr in the two groups decreased,and the decrease in the observation group was more significant than in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Kidney-tonifying and Blood-activating Decoction combined with cyclophosphamide is effective and safe in the treatment of refractory nephrotic syndrome.

关 键 词：难治性肾病综合征 补肾活血汤 环磷酰胺 对照治疗观察 

分 类 号：R692[医药卫生—泌尿科学]