补肾祛瘀汤治疗老年肾虚血瘀证骨质疏松症患者的效果  

Effect of Bushen Quyu Tang on elderly patients with osteoporosis of kidney deficiency and blood stasis syndrome

作　　者：李俊 周文彬 蔡丹宇 陈建生 LI Jun;ZHOU Wenbin;CAI Danyu;CHEN Jiansheng(Department of Bone Injury,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu Province,Suzhou215101,China)

机构地区：[1]江苏省苏州市中西医结合医院骨伤二科,江苏苏州215101

出　　处：《中国医药导报》2024年第7期162-165,共4页China Medical Herald

基　　金：江苏省研究生科研与实践创新计划项目(SJCX20-0616)。

摘　　要：目的 探讨补肾祛瘀汤治疗老年骨质疏松症(OP)患者的临床效果。方法 选取2018年1月至2022年12月江苏省苏州市中西医结合医院收治的老年OP患者160例,采用随机数字表法将其分为补肾祛瘀组和西药组,各80例。西药组给予碳酸钙D3片+阿法骨化醇片治疗,补肾祛瘀组在西药组基础上加用补肾祛瘀汤。比较两组临床疗效;比较两组治疗前后中医证候积分、骨密度(腰椎、股骨颈)、骨代谢指标[骨特异性碱性磷酸酶(BALP)、Ⅰ型原胶原N-端前肽(PINP)、抗酒石酸酸性磷酸酶(TRACP-5b)、Ⅰ型原胶原C-端前肽(CTX)]水平;比较两组不良反应发生率。结果 两组各有2例患者中途退出研究。补肾祛瘀组临床疗效优于西药组,差异有统计学意义(P<0.05)。治疗后,两组中医证候积分均低于治疗前,且补肾祛瘀组低于西药组,差异有统计学意义(P<0.05)。治疗后,两组腰椎和股骨颈骨密度均高于治疗前,且补肾祛瘀组高于西药组,差异有统计学意义(P<0.05)。治疗后,两组PINP、CTX及补肾祛瘀组BALP、TRACP-5b均低于治疗前,差异有统计学意义(P<0.05)。补肾祛瘀组BALP、TRACP-5b、PINP、CTX低于西药组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 补肾祛瘀汤联合西药用于治疗老年OP可有效改善患者临床症状,调节骨代谢转换平衡,增加骨密度。Objective To investigate the clinical effect of Bushen Quyu Tang in the treatment of elderly patients with osteoporosis(OP).Methods A total of 160 cases of elderly OP patients admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to December 2022 were selected and they were divided into invigorating the kidney and dispelling stasis group and western medicine group by random number table method,with 80 cases in each group.The western medicine group was given Calcium Carbonate D3 Tablets+Alfacalcitol Tablets for treatment,and the invigorating the kidney and dispelling stasis group was given Bushen Quyu Tang on the basis of the western medicine group.The clinical effect of the two groups was compared.The traditional Chinese medicine syndrome score,bone mineral density(lumbar spine,femoral neck),and bone metabolism indexes(bone specific alkaline phosphatase[BALP],cross-linked N-terminal propeptide of typeⅠcollagen[PINP],tartrate-resistant acid phosphatase[TRACP-5b]and C-terminal pro-peptide of type I collagen[CTX])were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups.Results A total of 2 patients in each of the two groups withdrew from the study halfway.The clinical effect of invigorating the kidney and dispelling stasis group was better than that of western medicine group,and the differences were statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than before treatment,and the invigorating kidney and dispelling stasis group was lower than the western medicine group,the differences were statistically significant(P<0.05).After treatment,bone mineral bone of lumbar spine and femoral neck in both groups were higher than before treatment,and the invigorating the and dispelling stasis group was higher than the western medicine group,the differences were statistically significant(P<0.05).After treatment,the BALP,TRACP-5b

关 键 词：补肾祛瘀汤 老年 骨质疏松症 骨密度 骨代谢 碳酸钙D3 阿法骨化醇片 

分 类 号：R274.19[医药卫生—中医骨伤科学]