基于心脏磁共振特征追踪技术的心肌应变评估心肌淀粉样变性患者的预后  

The Prognostic Value of Left Ventricular Myocardial Strain Parameters Derived from Cardiac Magnetic Resonance Feature Tracking Technique in Light-Chain Cardiac Amyloidosis Patients

作　　者：刘佳[1] 李玮[1] 马为[2] 王智[2] 奈日乐 赵凯[1] 何江凯 徐莎莎[1] 连健秀 邱建星[1] LIU Jia;LI Wei;MA Wei;WANG Zhi;NAI Rile;ZHAO Kai;HE Jiangkai;XU Shasha;LIAN Jianxiu;QIU Jianxing(Radiology Department,Peking University First Hospital,Beijing 100034,China;Cardiovascular Department,Peking University First Hospital,Beijing 100034,China;School of Biological Science and Medical Engineering,Beihang University)

机构地区：[1]北京大学第一医院医学影像科,北京100034 [2]北京大学第一医院心血管内科,北京100034 [3]北京航空航天大学生物与医学工程学院

出　　处：《中国医学计算机成像杂志》2024年第2期180-185,共6页Chinese Computed Medical Imaging

基　　金：ATTR-CM流行病研究基金(2022-CCA-ATTR-CM-019)。

摘　　要：目的:探讨基于心脏磁共振特征追踪(CMR?FT)技术的左心室心肌应变评估心肌淀粉样变性(CA)患者预后的可行性。方法:回顾性分析我院确诊并行CMR检查的33例轻链型CA患者,使用CVI42软件测量左心室整体和各节段(基底段、中间段、心尖段)水平的3D径向应变(RS)、周向应变(CS)、纵向应变(LS),通过随访生存时间,比较两组患者的预后结果。结果:Kaplan-Meier生存曲线表明RS_(Basal)、RS_(Mid)、CS_(Basal)绝对值降低,患者预后较差(χ^(2)=8.177,8.386,8.386;P=0.004,0.004,0.003)。结论:CMR-FT技术用于左心室的心肌应变,特别是RS_(Basal)、RS_(Mid)、CS_(Basal)对于评估CA患者的预后存在临床价值。Purpose:To explore the prognostic value of cardiac magnetic resonance feature tracking(CMR-FT)technique in quantitative assessment of left ventricular myocardial strain in patients with light-chain cardiac amyloidosis(AL-CA).Methods:A total of 33 AL-CA patients underwent CMR examination.CMR-FT technique was used to measure three-dimensional(3D)basal,mid,apical and global myocardium radial strain(RS),circumferential strain(CS)and longitudinal strain(LS)of left ventricle with CVI42.Receiver operating characteristic(ROC)curves were used to estimate the value of left ventricular myocardial strain parameters to predict the mortality.Kaplan-Meier curves were used to estimate the distribution of survival as a function of the follow-up duration.Results:Kaplan-Meier curves showed reduced RS_(Basal),RS_(Mid)and CS_(Basal)values resulted in worse prognosis(χ^(2)=8.177,8.386,8.386;P=0.004,0.004,0.003).Conclusions:Left ventricular myocardial strain parameters derived from CMR-FT may offer independent prognostic information for all-cause mortality in patients with AL-CA.Patients with reduced RS_(Basal),RS_(Mid)and CS_(Basal)are at the highest risk for death.

关 键 词：心脏磁共振 特征追踪 心肌应变 心肌淀粉样变性 预后 

分 类 号：R445.2[医药卫生—影像医学与核医学]