允许性高碳酸血症在临床中的应用进展  

Advances in clinical application of permissive hypercapnia

作　　者：王玲 钟毅 单热爱 WANG Ling;ZHONG Yi;SHAN Re-ai(The First Clinical Medical School,Gannan Medical University;Department of Anesthesiology,The First Affiliated Hospital of Gannan Medical University;Ganzhou Key Laboratory of Anesthesiology;Institute of Pain Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医科大学第一临床医学院 [2]赣南医科大学第一附属医院麻醉手术中心 [3]赣州市麻醉学重点实验室 [4]赣南医科大学疼痛医学研究所,江西赣州341000

出　　处：《赣南医学院学报》2024年第4期404-408,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省研究生创新专项资金项目(YC2022-S958);赣州市指导性科技计划项目(GZ2023ZSF130)。

摘　　要：允许性高碳酸血症在临床上已不仅局限于肺保护的应用,还具有多器官保护作用。本文就允许性高碳酸血症的多器官保护作用及机制进行综述,文献复习结果发现允许性高碳酸血症能够通过抗炎、抗氧化应激减少细胞凋亡、改善组织氧合,对肺、脑产生保护作用;此外还能通过改善线粒体结构、改善心肌缺血再灌注损伤等对脑、心脏具有保护作用,这些发现将为允许性高碳酸血症的后期研究及不同的临床应用提供参考。Permissive hypercapnia is not limited only to the application of lung protection clinically,it also has a multi-organ protective effect.This review summarizes the multi-organ protective effects and mechanism of permissible hypercapnia.The literature review results found that the protective effects of permissible hypercapnia can reduce apoptosis through anti-inflammation and anti-oxidative stress,and improve tissue oxygenation on lungs and brain by improving mitochondrial structure and myocardial ischemia-reperfusion injury.These findings provide reference for the later study and different clinical applications of permissible hypercapnia.

关 键 词：允许性高碳酸血症 多器官保护 肺保护 

分 类 号：R614.27[医药卫生—麻醉学]