糖尿病血管内皮功能损伤机制及无创评估的研究进展  

Research progress on the mechanism and noninvasive assessment of vascular endothelial dysfunction in diabetes mellitus

作　　者：沈诗意 武晓泓 Shen Shiyi;Wu Xiaohong(Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Endocrinology,Zhejiang Provincial People's Hospital,Hangzhou 310014,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江省人民医院内分泌科,杭州310014

出　　处：《国际内分泌代谢杂志》2024年第1期35-38,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81970714);浙江省自然科学基金联合基金资助项目(LHDMZ23H070001);浙江省“高层次人才特殊支持计划”科技领军人才项目(2021R52022);卫生创新人才项目(2021-CXRC07-01)。

摘　　要：糖尿病(diabetes mellitus)是一种以高血糖为特征的慢性疾病,其患病率在全球范围内不断上升。心血管病变是糖尿病最主要的并发症之一,具有治疗难度大、病情进展快及死亡率高的特征。血管内皮功能受损是诱发糖尿病心血管并发症的始动环节,其持续存在可以作为评估心血管并发症发生风险的一个重要指标。本文综述了糖尿病患者血管内皮功能损伤的机制及无创评估方式研究进展,以期在糖尿病患者中,早期发现并及时干预内皮功能损伤,降低心血管事件的发生风险。Diabetes mellitus(DM)is a chronic disease characterized by hyperglycemia,the prevalence of which is increasing worldwide.Cardiovascular disease is one of the main complication of DM,which is characterized by high treatment difficulty,rapid progression,and high mortality.Vascular endothelial dysfunction is the initiating link in the development of diabetic cardiovascular complications,and its persistence can be an important indicator in assessing the risk of vascular complications.This article reviews the research progress on the mechanism and noninvasive assessment of vascular endothelial dysfunction in patients with DM,with the aim of early detection and timely intervention of endothelial function impairment to reduce the risk of cardiovascular events in patients with DM.

关 键 词：糖尿病 内皮功能损伤 机制 评估方式 

分 类 号：R587.2[医药卫生—内分泌]