Antifertility effects of EP-1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans)  

作　　者：Jing LIU Feiyun TU Ming LIU Jichao WANG Zhibin ZHANG 

机构地区：[1]Ministry of Education Key Laboratory for Ecology of Tropical Islands,Key Laboratory of Tropical Animal and Plant Ecology of Hainan Province,College of Life Sciences,Hainan Normal University,Haikou,Hainan,China [2]Secretariat Office,International Society of Zoological Science and Society and Journal Office,Institute of Zoology,Chinese Academy of Sciences,Beijing,China [3]State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing,China [4]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing,China

出　　处：《Integrative Zoology》2024年第1期127-142,共16页整合动物学（英文版）

基　　金：The research was supported by the specific re-search fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202112);The State Key Laboratory of Integrated Management of Pest Insects and Rodents(Grant No.IPM2103);the 2022 PhD Launch Fund to Jing Liu(RC2200002593).

摘　　要：Pest rodents pose a serious threat to island biodiversity.Fertility control could be an alternative approach to control the impact of rodents on these islands.In this study,we examined the antifertility effects of EP-1 baits containing quinestrol(E)and levonorgestrel(P)using a dose of 50 ppm E and P at three different ratios(E:P ratio=1:2,1:1,and 2:1)on Pacific rats(Rattus exulans)in the Xisha Islands,Hainan,China.Compared to the control group,all animals in EP-1 treatment groups showed significantly decreased food intake and body weight.In treated males,there were obvious abnormalities in testis structure and a significant decrease of relative seminal vesicle weight,but no significant effect on relative uterine and ovarian weights(g kg-1 body weight),or ovarian structure in females.Adding 8%sucrose to the original 50-ppm baits(E:P ratio=1:1)significantly increased bait palatability for males and females.This dose induced uterine edema and abnormalities of ovarian structure in females but had no significant negative effect on the relative testis,epididymis,and seminal vesicle weights(g kg-1 body weight)or sperm density in males.In summary,50-ppm EP-1(1:1)baits have the potential to disrupt the fertility of females,and 8%sucrose addition to the EP-1 baits(E:P ratio=1:1)could improve bait palatability.This dose disrupted the testis structure in males.Future studies are needed to improve bait acceptance and assess the antifertility effects of EP-1(1:1)on Pacific rats in captive breeding trials and underfield conditions.

关 键 词：EP-1 fertility control island biodiversity conservation LEVONORGESTREL QUINESTROL Rattus exulans 

分 类 号：Q95[生物学—动物学]