The combined effect of bromadiolone and ivermectin (iBr) in controlling both rodents and their fleas  

作　　者：Ming LIU Xinrong WAN Wei LIU Xingan MA Zhibin ZHANG 

机构地区：[1]State Key Laboratory of Integrated Pest Management,Institute of Zoology,Chinese Academy of Sciences,Beijing,China [2]CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing,China [3]Inner Mongolia Minzu University,Tongliao,Inner Mongolia,China [4]International Society of Zoological Sciences,Beijing,China

出　　处：《Integrative Zoology》2024年第1期156-164,共9页整合动物学（英文版）

基　　金：We are grateful to the grant supported by Science and Technology Service Network Initiative of the Chinese Academy of Sciences(KFJ-STS-ZDTP-2021-002).

摘　　要：Rodent pests not only cause severe agricultural loss but also spread zoonotic pathogens to human beings.Antico-agulant rodenticides are widely used to decrease the population densities of rodents but often lead to the spillover of ectoparasites becausefleas and ticks may gather on surviving rodents.Therefore,it is necessary to killfleas and ticks before culling rodents to minimize the risk of pathogen transmission.In this study,we used a mixture of ivermectin(an antiparasitic drug)and bromadiolone(an anticoagulant rodenticide)to control both rodent andflea/tick abundances.We found that in a laboratory test,0.01%ivermectin bait was not lethal for greater long-tailed hamsters after 7 days of treatment,while 0.1%ivermectin bait was lethal for approximately 33%of treated rodents.In afield test,bait containing 0.001%,0.005%,0.01%,and 0.05%ivermectin decreased the number offleas per vole of Brandt’s voles to 0.42,0.22,0.12,and 0.2,respectively,compared with 0.77 in the control group,indicating that 0.01%ivermectin bait performed best in removingfleas.In another laboratory test,bait containing a 0.01%ivermectin and 0.005%bromadiolone mixture caused the death of all voles within 6–14 days after the intake of the bait.In thefield test,the bait containing 0.01%ivermectin and 0.005%bromadiolone reduced the average number offleas per vole to 0.35,which was significantly lower than the 0.77 of the control group.Our results indicate that a 0.01%ivermectin and 0.005%bromadiolone mixture could be used to control both rodents andfleas to minimize the spillover risk of disease transmission when using traditional rodenticides.

关 键 词：BROMADIOLONE FLEA IBR IVERMECTIN rodent synergistic control 

分 类 号：Q95[生物学—动物学]