DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm  

作　　者：Ying Lu Lanfang Li Hanting Yang Bin Li Zuoyun Wang 

机构地区：[1]Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education,Shanghai Xuhui Central Hospital and School of Basic Medical Sciences,Fudan University,Shanghai 200032,China [2]Institute for Translational Brain Research,State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China [3]Center for Immune-Related Diseases at Shanghai Institute of Immunology,Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

出　　处：《The Innovation》2024年第3期15-16,共2页创新（英文）

基　　金：National Key R&D Program of China(2022YFA1106400 to Z.W.and Y.L.and 2020YFA0803201 to Z.W.);National Natural Science Foundation of China(32270886 and 32070827 to Z.W.,82273235 and 82003012 to Y.L.,and 32171216 to H.Y.);STI2030-Major Projects(2022ZD0212600 to H.Y.).

摘　　要：In the latest issue of Nature,Zhang et al.characterized a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural biology,cell biology,and bioinformatics analyses.1 In this commentary,we highlight their key findings and provide our insights into the research paradigm for further exploration of a novel transcriptional regulation mode as well as a therapeutic strategy from the structural aspects of the FOXP3 complex(Figure 1).

关 键 词：FOXP3 BRIDGING 

分 类 号：Q523[生物学—生物化学] Q78