阿司匹林预防子痫前期:从证据到应用规范  

Aspirin in prevention of preeclampsia:from evidence to practice

作　　者：李健鑫 陈真[1] 漆洪波[1] Li Jianxin;Chen Zhen;Qi Hongbo(Department of Obstetrics and Gynecology,Women and Children's Hospital of Chongqing Medical University(Chongqing Health Center for Women and Children),Chongqing 401120,China)

机构地区：[1]重庆医科大学附属妇女儿童医院(重庆市妇幼保健院)妇产科,重庆401120

出　　处：《中华围产医学杂志》2024年第4期265-271,共7页Chinese Journal of Perinatal Medicine

基　　金：国家自然科学基金联合基金(U21A20346)。

摘　　要：子痫前期是引起孕产妇死亡、医源性早产、围产儿死亡的重要原因之一。半个多世纪前就有学者发现使用低剂量阿司匹林可以降低高危孕妇子痫前期的发生率,此后关于阿司匹林预防子痫前期的研究在全球范围内不断出现。目前的研究证实,阿司匹林可预防子痫前期的发生,但如何进一步探究其预防作用机制、如何规范使用阿司匹林以期达到理想的效果,仍是母胎医学的研究方向,尤其是应该从阿司匹林预防子痫前期的研究得到启发,探索老药新用在产科重大疾病的预防和治疗前景。Preeclampsia is one of the important causes of maternal death,iatrogenic premature birth,and perinatal death.More than half a century ago,researchers found that low-dose aspirin could reduce the incidence of preeclampsia in high-risk pregnant women,and since then,studies on aspirin for prevention of preeclampsia have continued to emerge worldwide.Current studies have clearly confirmed that aspirin can prevent the occurrence of preeclampsia.However,further exploration of its preventive mechanism and the establishment of a standard protocol for aspirin use to achieve the desired effect remain the directions in maternal-fetal medicine research.In particular,it should be inspired by the research on aspirin for prevention of preeclampsia,and explore the prevention and treatment prospects of old drugs with new application in major obstetric diseases.

关 键 词：阿司匹林 子痫前期 预防 

分 类 号：R714.244[医药卫生—妇产科学]