钾离子通道Eag1在肿瘤中的研究进展  

Research progress of potassium ion channel Eag1 in tumor

作　　者：王徐朝[1] 王博畅 陈娅斐[1] 展永[1] 刘文欣 安海龙[1] WANG Xu-zhao;WANG Bo-chang;CHEN Ya-fei;ZHAN Yong;LIU Wen-xin;AN Hai-long(Hebei Province Key Laboratory of Molecular Biophysics,Institute of Biophysics Hebei University of Technology,Tianjin 300401,China;Dept of Gynecological Oncology,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Tianjin′s Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China;Tianjin Tumor Hospital Airport Hospital,National Clinical Research Center for Cancer,Tianjin 300308,China)

机构地区：[1]河北省分子生物物理重点实验室,河北工业大学生物物理研究所,天津300401 [2]天津医科大学肿瘤医院妇科肿瘤科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津300060 [3]天津市肿瘤医院空港医院,国家恶性肿瘤临床医学研究中心,天津300308

出　　处：《中国药理学通报》2024年第5期823-828,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目(No 11735006);天津市科技计划项目(No 20JCZXJC00100);天津市教委科研计划项目(No 2019ZD033);河北省自然科学基金项目(No C2021202001);河北省高层次人才资助项目(No B2021003022);天津市医学重点学科(专科)建设项目(No TJYXZDXK-009A)。

摘　　要：Eag1(ether-à-go-go-1,又称Kv10.1、KCNH1)是电压门控钾离子(potassium,K+)通道KCNH基因家族成员,主要在中枢神经系统以及多种恶性肿瘤中表达,并在肿瘤的发生发展过程中起到重要的作用。研究Eag1的分布和作用机制对揭示其生理功能以及与病理机制具有十分重要的意义。该文综述了目前Eag1的生理和病理特性,Eag1与肿瘤发展演化的关系以及Eag1调节剂抗肿瘤应用的研究进展。Eag1(ether-à-go-go-1,also known as Kv10.1,KCNH1)is a member of the KCNH gene family of voltage-gated potassiumion(K+)channels,which is mainly expressed in the central nervous system as well as in a variety of malignancies and plays an important role in tumor development.The study of the distribution and mechanism of action of Eag1 is of great importance to reveal its physiological function and its association with pathological mechanisms.This paper reviews the current research progress on the physiological and pathological properties of Eag1,the relationship between Eag1 and tumor development and the anti-tumor application of Eag1 modulators.

关 键 词：Eag1 离子通道 生理特征 肿瘤 调控机制 调节剂 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R730.2[医药卫生—基础医学]