特发性肺纤维化的炎症机制与潜在药物靶标  

Inflammatory mechanisms and potential drug targets in idiopathic pulmonary fibrosis

作　　者：韩晓静 韩齐齐 钱峰 HAN Xiao-jing;HAN Qi-qi;QIAN Feng(Anhui Provincial Key Laboratory of Cancer Translational Medicine,Bengbu Medical University,Bengbu,Anhui 233000,China;School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]蚌埠医科大学癌症转化医学安徽省重点实验室,安徽蚌埠233000 [2]上海交通大学药学院,上海200240

出　　处：《中国药理学通报》2024年第5期828-832,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81973329,82173821);安徽省重点研发与开发计划项目(No 21210004)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进行性的、治愈难度大的慢性间充质性肺疾病。导致肺纤维化的因素有很多,例如:吸烟、外界环境污染、药物、病毒感染等。肺泡上皮损伤,肌成纤维细胞增多和胶原纤维沉积是特发性肺纤维化的特征,进而导致功能性气体交换障碍,呼吸衰竭甚至死亡。IPF发病原因不明且缺乏治愈的特效药,所以,探究肺纤维化的发病机制,寻找新的治疗策略十分迫切。在这篇综述中,我们总结了巨噬细胞介导肺纤维化的炎症机制,成纤维细胞在特发性肺纤维化中的作用,以及可能存在的潜在药物靶标。Idiopathic pulmonary fibrosis(IPF)is a progressive,chronic mesenchymal lung disease,which is difficult to cure.There are many factors that lead to pulmonary fibrosis,such as smoking,external environmental pollution,drugs,viral infections,etc.Alveolar epithelial injury,myofibroblast growth,and collagen deposition are characteristics of idiopathic pulmonary fibrosis,which in turn leads to dysfunction of functional gas exchange,respiratory failure,and even death.The pathological mechanism of IPF is unknown and there is a lack of curative drugs,and the morbidity and mortality rate remain high.Therefore,it is urgent to explore the pathogenesis of pulmonary fibrosis and find new treatment strategies.In this review,we summarize the inflammatory mechanisms by which macrophages mediate pulmonary fibrosis,the role of fibroblasts in idiopathic pulmonary fibrosis,and the possible potential drug targets.

关 键 词：特发性纤维化 巨噬细胞 炎症反应 炎症介质 成纤维细胞 潜在药物靶标 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R364.5[医药卫生—基础医学] R563.13R563.130.5