肾阴亏虚型2型糖尿病患者的六味地黄丸加减治疗效果及对血糖的影响  

Effect of Addition and Reduction of Liuwei Dihuang Pills and Its Influence on Blood Glucose in Patients with Type 2 Diabetes Mellitus with Kidneyyin Deficiency

作　　者：罗忠金 张丽国 LUO Zhongjin;ZHANG Liguo(Department of Internal Medicine,Zherong County Hospital of Traditional Chinese Medicine,Ningde,Fujian Province,355300 China;Department of General Practice,Zherong County Huangbai Health Center,Ningde,Fujian Province,355300 China)

机构地区：[1]柘荣县中医院内科,福建宁德355300 [2]柘荣县黄柏卫生院全科,福建宁德355300

出　　处：《糖尿病新世界》2024年第4期1-4,12,共5页Diabetes New World Magazine

摘　　要：目的探讨六味地黄丸加减治疗对肾阴亏虚型2型糖尿病患者的影响。方法选取2019年6月—2023年6月柘荣县中医院收治的79例肾阴亏虚型2型糖尿病患者为研究对象,按照随机投掷法将患者分为两组,即观察组(40例,给予盐酸二甲双胍片+六味地黄丸加减治疗)和对照组(39例,给予盐酸二甲双胍片治疗)。比较两组血糖水平、炎症反应[C-反应蛋白(C-Reactive Protein,CRP)、肿瘤坏死因子-α(Tumor Necrosis Fac⁃tor-α,TNF-α)及白细胞介素-6(Interleukin-6,IL-6)]、中医证候积分、治疗有效性及治疗安全性。结果治疗3个疗程后,观察组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白、CRP、TNF-α、IL-6水平低于对照组,差异有统计学意义(P均<0.05)。观察组中医证候评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较(12.50%vs 10.26%),差异无统计学意义(P>0.05)。结论肾阴亏虚型2型糖尿病患者经六味地黄丸加减治疗后,疗效突出,其不仅能有效控制血糖水平,还能积极促进机体微炎症状态的改善,进而缓解患者的临床症状。Objective To investigate the effect of addition and reduction of Liuwei Dihuang pill on type 2 diabetes pa⁃tients with kidney-yin deficiency.Methods A total of 79 patients with type 2 diabetes mellitus with kidney-yin defi⁃ciency admitted to Zherong County Hospital of Traditional Chinese Medicine from June 2019 to June 2023 were se⁃lected as the study objects,and the patients were divided into two groups according to random throwing method,namely observation group(40 cases,treated with metformin hydrochloride tablets+addition and reduction of Liwei Di⁃huang pills)and control group(39 cases,treated with metformin hydrochloride tablets).Blood glucose level,inflamma⁃tory response[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)],traditional Chi⁃nese medicine(TCM)symptom score,treatment effectiveness and treatment safety were compared between the two groups.Results After three sessions of treatment,the levels of fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,CRP,TNF-αand IL-6 in observation group were lower than those in control group,and the dif⁃ferences were statistically significant(all P<0.05).The TCM syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the obser⁃vation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(12.50%vs 10.26%)(P>0.05).Conclusion After treatment with addition and reduction of Liuwei Dihuang pill,the curative ef⁃fect is outstanding,which can not only effectively control blood glucose level,but also actively promote the improve⁃ment of micro-inflammatory state of the body,and then alleviate the clinical symptoms of patients.

关 键 词：肾阴亏虚型 2型糖尿病 六味地黄丸 盐酸二甲双胍片 

分 类 号：R587.1[医药卫生—内分泌]