探究2型糖尿病患者采用双胍类降糖药物的治疗效果  

Exploring the Therapeutic Effect of Adopting Biguanide Glucose-lowering Drugs in Patients with Type 2 Diabetes Mellitus

作　　者：何军[1] HE Jun(Department of Pharmacy,Tengzhou Maternal and Child Health Hospital,Tengzhou,Shandong Province,277599 China)

机构地区：[1]滕州市妇幼保健院药学部,山东滕州277599

出　　处：《糖尿病新世界》2024年第4期111-114,共4页Diabetes New World Magazine

摘　　要：目的探究2型糖尿病应用双胍类降糖药物的疗效。方法选取2023年1—12月滕州市妇幼保健院收治的80例2型糖尿病为研究对象,根据随机数表法分为对照组和观察组,各40例。对照组口服瑞格列奈片,观察组口服双胍类降糖药物二甲双胍片,持续用药8周后,对比两组血糖、胰岛功能及不良反应。结果两组治疗前的血糖及胰岛功能比较,差异无统计学意义(P均>0.05);治疗4、8周后,观察组的血糖及胰岛功能更优于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论2型糖尿病患者应用双胍类降糖药物二甲双胍片治疗,可改善血糖与胰岛功能,可减少不良反应。Objective To explore the efficacy of the application of biguanide glucose-lowering drugs in type 2 diabe⁃tes mellitus.Methods 80 cases of type 2 diabetes mellitus patients admitted to Tengzhou Maternal and Child Health Hospital from January to December 2023 were randomly selected as the study objects.All patients were divided into the control group and the observation group according to the method of randomized number table,with 40 cases in each group.The control group was given oral repaglinide tablets and the observation group was given oral biguanide glucose-lowering drug metformin tablets,and the two groups were compared with each other in terms of blood glucose,pancreatic islet function,and adverse reactions after 8 weeks of continuous medication.Results There was no statisti⁃cally significant difference in blood glucose and pancreatic islet function between the two groups before treatment(all P>0.05);after 4 and 8 weeks of treatment,the blood glucose and pancreatic islet function in the observation group were better than those in the control group,the differences were statistically significant(all P<0.05).The total inci⁃dence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of biguanide glucose-lowering drug metformin tablets in type 2 diabetes mellitus patients can improve blood glucose and pancreatic islet function,it can also reduce the ad⁃verse reactions.

关 键 词：双胍类降糖药物 瑞格列奈片 2型糖尿病 血糖 胰岛功能 

分 类 号：R9[医药卫生—药学]