2型糖尿病肾病患者尿白蛋白肌酐比与视网膜微循环参数的相关性研究  

Correlation between Urinary Albumin Creatinine Ratio and Retinal Micro⁃circulation Parameters in Patients with Type 2 Diabetes Nephropathy

作　　者：张星宇 朱婧 刘瑶[1] ZHANG Xingyu;ZHU Jing;LIU Yao(Department of Ophthalmology,the Third Affiliated Hospital of Soochow University,Changzhou,Jiangsu Province,213000 China;Department of Ophthalmology,Changzhou Geriatric Hospital Affiliated to Soochow University,Changzhou,Jiangsu Province,213000 China;Department of Endocrinology,the Third Affiliated Hospital of Soochow University,Changzhou,Jiangsu Province,213000 China)

机构地区：[1]苏州大学附属第三医院眼科,江苏常州213000 [2]苏州大学附属常州老年病医院眼科,江苏常州213000 [3]苏州大学附属第三医院内分泌科,江苏常州213000

出　　处：《糖尿病新世界》2024年第4期164-167,共4页Diabetes New World Magazine

摘　　要：目的研究2型糖尿病肾病患者尿白蛋白肌酐比(Urinary Albumin Creatinine Ratio,UACR)和视网膜微循环各项参数的相关性。方法选取2022年3—12月苏州大学附属第三医院及苏州大学附属常州老年病医院收治的95例2型糖尿病肾病患者为研究对象。根据UACR水平分为U1组(UACR<10 mg/g,28例,28眼)、U2组(UACR:10~30 mg/g,46例,46眼)、U3组(UACR:30~300 mg/g,21例,21眼)。利用光学相干断层成像,测量3组患者黄斑中心凹区和旁中心凹区浅层毛细血管丛血流密度(Superficial Capillary Plexus Vessel Den⁃sity,SCP-VD)、深层毛细血管丛血流密度(Deep Capillary Plexus Vessel Density,DCP-VD)、中心凹无血管区(Foveal Avascular Zone,FAZ)面积与周长,观察指标差异,分析指标与UACR相关性。结果3组患者中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD、FAZ面积比较,差异有统计学意义(P均<0.05);3组患者FAZ周长比较,差异无统计学意义(P>0.05);UACR与中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD负相关(r=-0.410、-0.689、-0.545、-0.627,P均<0.05),与FAZ面积正相关(r=0.463,P<0.05)。结论2型糖尿病患者UACR与中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD、FAZ面积存在相关性。OCTA视网膜微循环参数可作为糖尿病肾病损害程度的评估指标。Objective To study the correlation between urinary albumin creatinine ratio(UACR)and various param⁃eters of retinal microcirculation in patients with type 2 diabetes nephropathy.Methods Ninety-five patients with type 2 diabetic nephropathy admitted to the Third Affiliated Hospital of Soochow University and Changzhou Geriatric Hos⁃pital of Soochow University from March to December 2022 were selected as the study objects.According to UACR level,they were divided into U1 group(UACR<10 mg/g,28 cases,28 eyes),U2 group(UACR:10-30 mg/g,46 cases,46 eyes)and U3 group(UACR:30-300 mg/g,21 cases,21 eyes).Using optical coherence tomography,Superficial Capillary Plexus Vessel Density,superficial capillary plexus vessel density,superficial capillary plexus vessel density,superficial capillary plexus vessel density,Gold ascular Zone(SCP-VD),Deep Capillary Plexus Vessel Density(DCPVD),and Foveal Avascular Zone(FAZ)area and perimeter,and differences in observational parameters,The correla⁃tion between the index and UACR was analyzed.Results The areas of foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD,and FAZ were negatively correlation among 3 groups(all P<0.05).There was positively correlation in the circumference of FAZ among 3 groups(P>0.05).UACR was negatively correlated with foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD(r=-0.410,-0.689,-0.545,-0.627,all P<0.05),and positively correlated with FAZ area(r=0.463,P<0.05).Conclusion In type 2 diabetes mellitus,UACR was corre⁃lated with foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD,and FAZ area.Retinal micro⁃circulation parameters of OCTA can be used as an index to evaluate the damage degree of diabetic nephropathy.

关 键 词：眼底相干光层析血管成像术 尿白蛋白肌酐比 2型糖尿病 视网膜微循环 

分 类 号：R587[医药卫生—内分泌]