血液灌流与血液透析联合应用于糖尿病肾病终末期患者中的应用效果分析  

Effect of Hemoperfusion Combined with Hemodialysis in End-stage Pa⁃tients with Diabetes Nephropathy

作　　者：胡昌芝 崔建 HU Changzhi;CUI Jian(Department of Hemodialysis Room,Gaoqing County People's Hospital,Zibo,Shandong Province,256300 China;Department of Pharmacy,Zibo Maternal and Child Health Hospital,Zibo,Shandong Province,255000 China)

机构地区：[1]山东省淄博市高青县人民医院血液透析室,山东淄博256300 [2]淄博市妇幼保健院药学部,山东淄博255000

出　　处：《糖尿病新世界》2024年第4期168-170,178,共4页Diabetes New World Magazine

摘　　要：目的评价血液灌流和血液透析在糖尿病肾病终末期患者中的作用。方法选取2022年1月—2023年6月于山东省淄博市高青县人民医院透析的50例糖尿病肾病终末期患者为研究对象,按随机数表法将其分成两组,每组25名。单一治疗组给予单独透析治疗,联合治疗组给予全血灌流与全血透析治疗,对比分析两组疗效及并发症发生情况。结果联合治疗组患者的并发症总发生率低于单一治疗组,差异有统计学意义(P<0.05)。联合治疗组的治疗总有效率明显高于单一治疗组,差异有统计学意义(P<0.05)。联合治疗组患者的白细胞(White Blood Cell,WBC)、血红蛋白(Hemoglobin,Hb)、血小板(Platelet,PLT)等指标显著低于单一治疗组,而血尿素氮(Blood Urea Nitrogen,Bun)、血肌酐(Serum Creatinine,Scr)、钾离子等水平显著高于单一治疗组,差异有统计学意义(P均<0.05)。结论对于需要进行血透的肾损伤患者,给予血液灌流能够提高治疗效果,减少并发症。Objective To evaluate the role of hemoperfusion and hemodialysis in end-stage patients with diabetes ne⁃phropathy.Methods Fifty patients with end-stage diabetes nephropathy were undernent hemodialysis in Gaoqing County People's Hospital from January 2022 to June 2023 were selected and divided into two groups according to ran⁃dom number table,twenty-five patients in each group.The monotherapy group was given individual dialysis for treat⁃ment,while the combined treatment group was given whole hemoperfusion and hemodialysis for treatment.The effi⁃cacy and complications of the two groups were compared and analyzed.Results The total incidence of complications in the combined treatment group was lower than that in the monotherapy group,and the difference was statistically sig⁃nificant(P<0.05).The total effective rate of the combined treatment group was significantly higher than that of the monotherapy group,and the difference was statistically significant(P<0.05).The levels white blood cell(WBC),hemo⁃globin(Hb),platelets(PLT)of patients in the combined treatment group were significantly lower than those in the monotherapy group,while the levels of blood urea nitrogen(Bun),serum creatinine(Scr),potassium ions were signifi⁃cantly higher than those in the potassium ions group,and the differences were statistically significant(all P<0.05).Conclusion For patients with nephropathy who need hemodialysis,hemoperfusion can improve the therapeutic effect and reduce complications.

关 键 词：血液灌流 血液透析 联合应用 糖尿病肾病终末期 终末期 应用效果 

分 类 号：R4[医药卫生—临床医学]