胰激肽原酶肠溶片联合达格列净治疗糖尿病肾病的疗效分析  

Therapeutic Effect of Pancreatic Kallidinogenase Enteric Coated Tablets Combined with Dapagliflozin on Diabetes Nephropathy

作　　者：崔韶华 CUI Shaohua(Department of Nephrology,Qixia People's Hospital,Yantai,Shandong Province,265300 China)

机构地区：[1]栖霞市人民医院肾内科,山东烟台265300

出　　处：《糖尿病新世界》2024年第4期171-174,共4页Diabetes New World Magazine

摘　　要：目的探讨胰激肽原酶肠溶片联合达格列净治疗糖尿病肾病的疗效。方法选取2021年1月—2023年6月栖霞市人民医院收治的80例糖尿病肾病患者为研究对象,以随机数表法将其分为对照组及研究组,各40例。研究组接受胰激肽原酶肠溶片联合达格列净疗法治疗,对照组仅接受达格列净治疗。比较两组患者治疗前后的肾功能指标、血糖指标、炎症指标及生存质量。结果治疗前,两组患者肾功能、血糖、炎症指标及生存质量评分相比,差异无统计学意义(P均>0.05)。治疗后,两组患者血肌酐、24 h尿蛋白定量及血糖、炎症指标均下降,且研究组较对照组更低,差异有统计学意义(P均<0.05)。两组患者的血白蛋白、健康调查简表评分和糖尿病控制状况量表评分较治疗前升高,且研究组高于对照组,差异有统计学意义(P均<0.05)。结论胰激肽原酶肠溶片联合达格列净疗法能够有效改善糖尿病肾病患者的肾功能、血糖相关指标,减轻炎症反应,从而改善患者的肾脏预后,提高患者生存质量。Objective To investigate the effect of pancreatic kininogenase enteric coated tablets combined with dapa⁃gliflozin in the treatment of diabetic nephropathy.Methods A total of eighty patients with diabetic nephropathy admit⁃ted to Qixia People's Hospital from January 2021 to June 2023 were selected as the study objects,and were divided into control group and study group by random number table method,with forty cases in each group.The study group received pancreatic kininogenase enteric coated tablets combined with dapagliflozin therapy,while the control group received only dapagliflozin therapy.Renal function indexes,blood glucose indexes,inflammation indexes and quality of life were compared between the two groups before and after treatment.Results Before treatment,there were no sig⁃nificant difference in renal function,blood glucose,inflammation index and quality of life score between two groups(all P>0.05).After treatment,serum creatinine,24 h urinary protein quantity,blood glucose and inflammation indexes were all decreased in two groups,and those of the study group were lower than the control group,and the differences were statistically significant(all P<0.05).The levels of blood albumin and scores of MOS Item Short From Health Sur⁃vey and Control Status Scale for Diabeties in two groups after treatment were higher than before treatment,and the val⁃ues in the study group were higher than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Pancreatic kininogenase enteric coated tablets combined with dapagliflozin therapy can effectively improve the renal function and blood glucose related indexes of diabetic nephropathy patients,reduce inflammatory re⁃sponse,thereby improving the renal prognosis of patients and improving the quality of life of patients.

关 键 词：胰激肽原酶肠溶片 达格列净 糖尿病肾病 肾功能 血糖 

分 类 号：R4[医药卫生—临床医学]