经皮肾动脉去交感神经术对射血分数保留的心力衰竭患者心功能的影响分析  

Effect of Percutaneous Renal Artery Desympathization on Cardiac Function in Patients With Heart Failure With Preserved Ejection Fraction

作　　者：王鹂檐 冯俊帆 尹刚 王朝涛 杨吟 阿衣子举 岳庆林 WANG Liyan;FENG Junfan;YIN Gang;WANG Chaotao;YANG Yin;AYI Ziju;YUE Qinglin(Department of Cardiovascular Medicine,Hanyuan County People's Hospital,Ya'an,Sichuan Province,625300 China)

机构地区：[1]汉源县人民医院心血管内科,四川雅安625300

出　　处：《系统医学》2024年第5期113-116,共4页Systems Medicine

基　　金：雅安市重点科技计划项目(22KJJHO012)。

摘　　要：目的探讨经皮肾动脉去交感神经术对射血分数保留的心力衰竭患者心功能的影响分析。方法选取2022年8月—2023年12月汉源县人民医院收治的68例射血分数保留的心力衰竭患者为研究对象,按照随机数表法分为两组,对照组(n=34)采用标准抗心衰药物治疗,观察组(n=34)联合经皮肾动脉去交感神经术治疗。比较两组心功能指标、6 min步行试验(6-minute Walking Test,6MWT)距离、血清N-末端脑钠肽前体水平及主要不良心血管事件发生率、再住院率。结果治疗后,观察组左心室射血分数水平、6MWT距离高于对照组,左心室收缩末期内径、左心室舒张末期内径及血清N-末端脑钠肽前体水平低于对照组,差异有统计学意义(P均<0.05)。观察组不良心血管事件发生率(5.88%)、再住院率(14.71%)均低于对照组,差异有统计学意义(χ^(2)=4.221、4.826,P均<0.05)。结论经皮肾动脉去交感神经术能改善射血分数保留的心力衰竭患者心功能,提高运动耐量,且能减少心血管负担及再住院率,安全性良好。Objective To explore the impact of percutaneous renal artery sympathetic denervation on cardiac function in heart failure patients with preserved ejection fraction.Methods A total of 68 patients with heart failure with pre⁃served ejection fraction admitted to Hanyuan County People's Hospital from August 2022 to December 2023 were se⁃lected as the study objects and divided into two groups according to the random number table method.The control group(n=34)was treated with standard anti-heart failure drugs,and the observation group(n=34)was treated with per⁃cutaneous renal artery sympathetic denervation.Cardiac function indexes,6-minute walking test(6 MWT)distance,serum N-terminal pro-brain natriuretic peptide level,incidence of major adverse cardiovascular events and rehospital⁃ization rate were compared between the two groups.Results After treatment,the left ventricular ejection fraction level and 6 MWT distance in the observation group were higher than those in the control group,and the left ventricular endsystolic diameter,left ventricular end-diastolic diameter and serum N-terminal brain natriuretic peptide precursor level were lower than those in the control group,the differences were statistically significant(all P<0.05).The inci⁃dence of adverse cardiovascular events(5.88%)and rehospitalization rate(14.71%)in the observation group were lower than those in the control group,the differences were statistically significant(χ^(2)=4.221,4.826,both P<0.05).Conclusion Percutaneous renal artery desympathization can improve heart function and exercise tolerance in heart failure patients with preserved ejection fraction,reduce cardiovascular burden and readmission rate,and has good safety.

关 键 词：慢性射血分数保留的心力衰竭 经皮肾动脉去交感神经术 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]