人工牛黄甲硝唑胶囊致男性患者外生殖器多形红斑型药疹的诊疗分析  

Analysis of Diagnosis and Treatment of Male Patients with Erythema Multiforme Drug Eruption on External Genitalia Caused by Artificial Bezoar Metronidazole Capsules

作　　者：初丽娟 吴涛[1] 王蓉华 CHU Li-juan;WU Tao;WANG Rong-hua(The Affiliated Weihai Second Hospital of Qingdao University,Weihai Shandong 264200,China)

机构地区：[1]青岛大学附属威海市立第二医院,山东威海264200

出　　处：《抗感染药学》2024年第2期136-138,共3页Anti-infection Pharmacy

摘　　要：目的:分析1例人工牛黄甲硝唑胶囊致男性患者外生殖器多形红斑型药疹的诊疗过程,为临床该药的用药安全提供参考。方法与结果:该患者因牙痛而自行购买人工牛黄甲硝唑胶囊服用,但第2天患者发现外生殖器不行米粒至豆粒大小的红斑,呈密集对称分布,伴轻微瘙痒,遂自行停药;但停药多日后仍未见好转,皮损还逐渐增大,且表面出现糜烂、渗出,遂入院治疗;入院后,对患者予以了抗炎、抗感染治疗,2周后患者红斑基本消失,1个月后患者皮损也基本痊愈;其间,医生采用诺氏评估量表考察多形红斑型药疹与人工牛黄甲硝唑胶囊的关联性,结果评分为6分,即关联性为“很可能”。结论:人工牛黄甲硝唑胶囊所致药疹仅出现在外生殖器部位而未涉及身体其他部位的情况较为罕见,临床在宣教时应做好用药交代,以便于患者早分辨、早治疗。Objective:To analyze the diagnosis and treatment process of one male patient with erythema multiforme drug eruption on the external genitalia caused by artificial bezoar metronidazole capsules,and provide reference for the clinical medication safety of such drugs.Methods and Results:The patient purchased and took artificial bezoar metronidazole capsules on his own because of toothache.However,on the second day,rice-to-bean-sized erythemas were found on his external genitalia,which were densely and symmetrically distributed with slight itching,so he discontinued the drugs on his own.Nonetheless,his symptoms were not relieved after discontinuing medication for many days,and the skin lesions gradually increased,and erosion and exudation appeared on the surfaces,so he was admitted to the hospital for treatment.After admission,the patient was given anti-inflammatory and anti-infective treatment.After 2 weeks,the patient's erythema basically disappeared;one month later,the patient's skin lesions were basically healed;during the period,the doctor used the Naranjo's Assessment Scale to investigate the correlation between erythema multiforme drug eruption and artificial bezoar metronidazole capsules.The assessment score was 6,i.e.the correlation was "very likely".Conclusion:It is rare for drug eruptions caused by artificial bezoar metronidazole capsules to appear on the external genitalia only without involving other body parts.Medication instructions should be given during clinical propaganda and education to facilitate early identification and early treatment for patients.

关 键 词：人工牛黄甲硝唑胶囊 男性患者 外生殖器 多形红斑型药疹 药物不良反应 

分 类 号：R978.19[医药卫生—药品] R758.25[医药卫生—药学]