基于文献的阿替卡因肾上腺素注射液所致过敏反应的流行病学分析  

Epidemiological Analysis of Anaphylactic Responses Caused by Atocaine Hydrochloride and Epinephrine Tartrate Injection Based on Literature

作　　者：潘丽丽[1] PAN Li-li(The Third People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第三人民医院,郑州450000

出　　处：《抗感染药学》2024年第2期139-143,共5页Anti-infection Pharmacy

摘　　要：目的:通过文献检索分析阿替卡因肾上腺素注射液(atocaine hydrochloride and epinephrine tartrate injection,AHETI)所致过敏反应的流行病学特点,为临床该药的用药安全提供参考。方法:以“阿替卡因肾上腺素注射液(atocaine hydrochloride and epinephrine tartrate injection)”“、过敏反应(anaphylaxis or anaphylactic response)”“、药物不良反应(adverse drug reaction)”等位关键词,在中国知网、万方数据库、重庆维普、PubMed、Springer、Elsevier等国内外数据库中检索截至2022年12月31日的所有相关案例文献,采集相关病例的年龄、性别、所患疾病和AHETI的用法用量,以及所致过敏反应的发生时间、严重程度、临床表现和转归情况等信息,分析AHETI所致过敏反应的流行病学特点。结果:在数据库中共检索到相关案例文献22篇,涉及病例23例;其中,性别上以女性为主(18例,占78.26%),年龄上以>20~40岁为主(12例,占52.17%);23例患者中,其诊断主要为牙髓炎(6例,占26.09%)、慢性牙周炎(5例,占21.74%)和拔牙术(4例,占17.39%),过敏反应的发生时间主要集中在用药后的10min内(12例,占52.17%),过敏反应主要的累及器官有皮肤及其附件、神经肌肉、循环系统和呼吸系统;经过对症处置,23例患者全部好转。结论:AHETI所致过敏反应在患者年龄和性别、发生时间和临床表现上有其特点,对此临床应积极关注,并做好防护,以保证患者的用药安全。Objective:To analyze the epidemiological characteristics of anaphylactic responses caused by atocaine hydrochloride and epinephrine tartrate injection(AHETI) through literature search,and provide reference for the clinical medication safety of this drug.Methods:By using the KEY WORDS such as "atocaine hydrochloride and epinephrine tartrate injection","anaphylaxis or anaphylactic response","adverse drug reaction",all relevant case documents as of December 31,2022 in Chinese and foreign databases such as CNKI,Wanfang Database,Chongqing VIP,PubMed,Springer,and Elsevier were searched.The information such as age,gender,disease of relevant cases,usage and dosage of AHETI,as well as occurrence time,severity,clinical manifestations and outcomes of anaphylactic responses was collected to analyze the epidemiological characteristics of anaphylactic responses caused by AHETI.Results:A total of22 relevant case documents were searched in databases,involving 23 cases;of which,most cases were females(18 cases,78.26%),elder than 20 to 40 years old(12 cases,52.17%);23 cases were mainly diagnosed with pulpitis(6 cases,26.09%),chronic periodontitis(5 cases,21.74%) and tooth extraction(4 cases,17.39%);the occurrence time of anaphylactic responses was mainly concentrated within 10 minutes after medication(12 cases,52.17%),and the main organs involved in anaphylactic responses included the skin and its appendages,neuromuscular,circulatory system and respiratory system.After symptomatic treatment,all 23 patients got better.Conclusion:Anaphylactic responses caused by AHETI have characteristics in terms of the patient's age and gender,occurrence time and clinical manifestations.Therefore,active attentions should be paid to them and protective measures should be taken to ensure the medication safety of patients.

关 键 词：阿替卡因肾上腺素注射液 过敏反应 流行病学特点 药物不良反应 

分 类 号：R982[医药卫生—药品] R181.35[医药卫生—药学]