维生素D不同给药时间对极低出生体质量早产儿支气管肺发育不良的影响  

Effect of different administration time of vitamin D on bronchopulmonary dysplasia in preterm infants with very low birth weight

作　　者：邓磊[1] 李思杰[1] 刘玮[1] 陈燕梅[1] 张寅[1] DENG Lei;LI Sijie;LIU Wei;CHEN Yanmei;ZHANG Yin(Department of Neonatal Mother and Infant Rooming-in,First People’s Hospital of Shangqiu City,Shangqiu 476100,Henan,China)

机构地区：[1]商丘市第一人民医院新生儿母婴同室科,河南商丘476100

出　　处：《中国校医》2024年第1期65-67,75,共4页Chinese Journal of School Doctor

摘　　要：目的 探究出生后7 d维生素D给药与出生后10 d维生素D给药对极低出生体质量早产儿支气管肺发育不良、血气分析、炎性因子及肺损伤指标的影响。方法 随机选取2021年12月—2022年12月本院收治的80例极低出生体质量早产儿为研究对象,采用软件随机数字生成法将编号为奇数的患儿纳入观察组,编号为偶数患儿纳入对照组,每组40例。观察组于出生后第7 d给予800单位维生素D,对照组于出生后第10 d给予800单位维生素D,比较2组早产儿的支气管肺发育不良(BPD)发生情况、血气分析、炎性因子及肺损伤指标。结果 观察组BPD发生率为5.00%,低于对照组的22.50%(χ^(2)=5.165,P=0.023)。治疗后,观察组PaO_(2)为(97.91±32.62)mmHg、a/APO_(2)为(0.48±0.15)、25(OH)D3为(14.63±4.86)ng/mL,高于对照组的(82.16±27.37)mmHg、(0.37±0.11)、(10.84±3.60)ng/mL,差异均有统计学意义(P均<0.05);观察组PaCO_(2)为(31.13±10.36)mmHg、OI为(10.13±3.36)、TNF-α为(90.63±15.09)pg/mL、IL-6为(80.91±13.47)pg/mL、CRP为(7.58±2.51)mg/L、sNGAL为(90.82±14.56)μg/L、TGF-β1为(9.08±3.02)ng/mL,低于对照组的(43.04±14.33)mmHg、(17.49±5.82)、(123.84±20.63)pg/mL、(115.16±19.18)pg/mL、(19.17±16.38)mg/L、(110.16±18.35)μg/L、(21.43±7.13)ng/mL,差异均有统计学意义(P均<0.05)。结论 出生后第7 d给予维生素D较第10 d补充维生素D更能维持患儿血气指标稳定,减轻炎症反应及肺组织损伤,降低BPD总发生率。Objective To investigate the effects of vitamin D administration 7 days after birth and vitamin D administration 10 days after birth on bronchopulmonary dysplasia(BPD),blood gas analysis,inflammatory factors,and lung injury index in preterm infants with very low birth weight.Methods A total of 80 preterm infants with very low birth weight admitted to our hospital from December 2021 to December 2022 were randomly selected as the study subjects,and the odd-numbered children were included in the observation group and the even-numbered children were included in the control group,with 40 cases in each group.The observation group was given 800 units of vitamin D on the 7th day after birth,and the control group was given 800 units of vitamin D on the 10th day after birth,and the incidence of BPD,blood gas analysis,inflammatory factors,and lung injury indexes of the two groups were compared.Results The incidence of BPD in the observation group was 5.00%,which was lower than that in the control group(22.50%)(χ^(2)=5.165,P=0.023).After treatment,the PaO_(2) in the observation group was(97.91±32.62)mmHg,a/APO_(2) was(0.48±0.15),and 25(OH)D3 was(14.63±4.86)ng/mL,which was higher than those in the control group:(82.16±27.37)mmHg,(0.37±0.11),(10.84±3.60)ng/mL,the differences were statistically significant(all P<0.05).In the observation group,PaCO_(2) levels were(31.13±10.36)mmHg,OI was(10.13±3.36),TNF-αwas(90.63±15.09)pg/mL,IL-6 was(80.91±13.47)pg/mL,CRP was(7.58±2.51)mg/L,and sNGAL was(90.82±The 14.56)μg/L,and TGF-β1 were(9.08±3.02)ng/mL,which were lower than those of the control group:(43.04±14.33)mmHg,(17.49±5.82),(123.84±20.63)pg/mL,(115.16±19.18)pg/mL,(19.17±16.38)mg/L,(110.16±18.35)μg/L,and(21.43±7.13)ng/mL,the differences were statistically significant(all P<0.05).Conclusion Compared with vitamin D supplementation on the 10th day,vitamin D administration on the 7th day after birth can maintain the stabilityof blood gas indexes,reduce inflammation and lung tissue damage,and reduce the overall inc

关 键 词：维生素D 极低出生体质量 早产儿 支气管肺发育不良 

分 类 号：R725[医药卫生—儿科]