microRNAs对心脏电生理特性影响的研究进展  

Research progress in the effects of microRNAs on cardiac electrophysiological properties

作　　者：易菁 高鸿 潘斯斯 YI Jing;GAO Hong;PAN Sisi(Department of Anesthesiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;不详)

机构地区：[1]贵州医科大学附属医院麻醉科,贵阳550004 [2]中山大学附属第一医院贵州医院麻醉科,贵阳550000 [3]贵州医科大学附属医院心脏外科,贵阳550004

出　　处：《实用医学杂志》2024年第9期1320-1323,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82360053);贵州省卫生健康委科学技术基金项目(编号:Gzwkj2021-270,Gzwkj2022-131);贵州省中医药、民族医药科学技术研究专项课题项目(编号:QZYY-2021-102)。

摘　　要：非心脏外科围术期心律失常的发生率4%~20%,而心胸外科围术期心律失常的发生率为10%~30%,其中心脏手术患者围术期心律失常的发生率高达90%。围术期心律失常可延长住院时间,增加患者住院期间的发病率和死亡率。研究表明,心血管疾病中存在的异常表达microRNAs可通过调控离子通道、缝隙连接蛋白及细胞内Ca2+处理蛋白等,参与心脏自律性、兴奋性以及传导性,从而调节心脏电生理稳态和心律失常。本文将主要从心脏电生理失衡的角度综述microRNA与心律失常的研究进展。The incidence of perioperative arrhythmias is 4%~20% in noncardiac surgery and 10% ~ 30% in cardiothoracic surgery, with the incidence of perioperative arrhythmias in cardiac surgery patients as high as 90%. Perioperative arrhythmias can prolong hospitalization and increase morbidity and mortality during hospitalization. Studies have shown that aberrantly expressed microRNAs in cardiovascular diseases can participate in cardiac auto⁃maticity, excitability and conductivity by regulating ion channels, gap junction proteins, and intracellular Ca2+ handling proteins, thereby regulating cardiac electrophysiological homeostasis and arrhythmias. In this article, we will review the research progress of microRNAs and arrhythmias mainly from the perspective of cardiac electrophysi⁃ological imbalance.

关 键 词：MICRORNA 心脏电生理 心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]