肿瘤多药耐药发生机制及中药逆转研究进展  

Research Progress of Mechanism of Tumor Multidrug Resistance and Reversal by Traditional Chinese Medicine

作　　者：刘彦娟 曹雨虹 匡荣 LIU Yanjuan;CAO Yuhong;KUANG Rong(Collaboration Innovation Center of Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310032,China;NMPA Key Laboratory for Animal Alternative Testing Technology of Cosmetics,Zhejiang Institute for Food and Drug Control,Hangzhou 310052,China;Institute of Translational Medicine,Zhejiang University,Hangzhou 310029,China)

机构地区：[1]浙江工业大学绿色制药协同创新中心,杭州310032 [2]浙江省食品药品检验研究院,国家药品监督管理局化妆品动物替代试验技术重点实验室,杭州310052 [3]浙江大学转化医学研究院,杭州310029

出　　处：《中国药学杂志》2024年第7期561-570,共10页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82204348)。

摘　　要：化疗是肿瘤治疗常用的手段之一,但肿瘤多药耐药(multidrug resistance,MDR)的发生给肿瘤治疗增加了巨大困难,对患者的生理和心理都造成了严重的伤害。目前临床上对肿瘤MDR的研究和治疗都相对欠缺,寻找肿瘤MDR的逆转剂和逆转策略也成了亟待解决的问题。笔者对肿瘤MDR发生机制、逆转手段以及中药作为逆转剂的研究进展进行综述,旨在为今后研究肿瘤MDR提供参考。Chemotherapy is one of the commonly used methods for tumor treatment,but the occurrence of multidrug resistance(MDR)in tumors has added great difficulties for tumor treatment,causing serious harm to patients′physiology and psychology.At present,there is a relative lack of research and treatment on tumor resistance in clinical practice,and finding reversal agents and strategies for tumor resistance is an urgent problem to be solved.This article reviews the mechanism of tumor multidrug resistance and its reversal methods and research status of Chinese medicine as reverse agent,aiming to provide reference for future research.

关 键 词：多药耐药 转运蛋白 P-糖蛋白 中药逆转 

分 类 号：R966[医药卫生—药理学]