真菌来源杂萜类化合物的研究进展  

Research Progress of Meroterpenoids Produced by Fungi

作　　者：时杰 余玥 刘冰 李文兰[1] SHI Jie;YU Yue;LIU Bing;LI Wenlan(College of Pharmacy,Harbin University of Commerce,Harbin 150076,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Beijing Academy of Science and Technology,Beijing 100089,China;Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,哈尔滨150076 [2]北京大学药学院天然与仿生药物国家重点实验室,北京100191 [3]北京市科学技术研究院,北京100089 [4]哈尔滨商业大学药物工程技术研究中心,哈尔滨150076

出　　处：《中国药学杂志》2024年第6期476-485,共10页Chinese Pharmaceutical Journal

基　　金：中央支持地方高校改革发展资金人才培养项目资助。

摘　　要：杂萜类化合物是一类含有萜类骨架的杂合型天然产物,具有独特的结构和多样的生物活性,在抗菌、抗炎、抗肿瘤等方面均有所体现,成为天然产物领域的研究热点。笔者综述近5年真菌来源杂萜类化合物的研究进展,基于生源特征归纳了其化学结构和生物活性,将为新型杂萜类药物的开发提供有力支撑。Meroterpenoids are a class of terpenoid-containing hybrid natural products with impressive structures and various bioactivities,which are reflected in antibacterial,anti-inflammatory,anti-tumor and other aspects,and have become a research hotspot in the field of natural products.Here,meroterpenoids isolated from fungi over the past 5 years are summarized.Their chemical structures and biological activities are summarized according to their biosynthetic origin.This review could provide strong support for developing new meroterpenoid-derived drugs.

关 键 词：杂萜类化合物 真菌 生物活性 生物合成 

分 类 号：R97[医药卫生—药品] R96[医药卫生—药学]