糖化白蛋白检测方法的研究进展  

Progress of Methods for Detection of Glycated Albumin

作　　者：胡琼 李诗琪 骆怡琳 曹晓静 梁伊依 冯文星 牛利 HU Qiong;LI Shi-Qi;LUO Yi-Lin;CAO Xiao-Jing;LIANG Yi-Yi;FENG Wen-Xing;NIU Li(Guangzhou Key Laboratory of Sensing Materials and Devices,Center for Advanced Analytical Science,School of Chemistry and Chemical Engineering,Guangzhou University,Guangzhou 510006,China)

机构地区：[1]广州大学化学化工学院,分析科学技术研究中心,广州市传感材料与器件重点实验室,广州510006

出　　处：《分析化学》2024年第3期306-312,共7页Chinese Journal of Analytical Chemistry

基　　金：广州市科技计划项目(Nos.202201010600,202201020170);广州大学大学生创新训练项目(Nos.202211078113,S202111078031);广东省基础与应用基础研究基金项目(No.2022A1515010618)资助。

摘　　要：糖尿病是一组以持续性高血糖为特征的慢性代谢性疾病,糖尿病及其并发症已成为严重的全球性公共卫生问题,但目前仍缺乏有效的治疗手段。血糖水平监测是糖尿病病情监测的一种有效手段。人血清白蛋白(HSA)与血液中的葡萄糖经非酶促糖基化反应的产物为糖化白蛋白(GA),因GA可反映过去2~3周内的总体血糖水平,可作为血清标志物,在糖尿病患者短期血糖控制评估、疗效观察以及治疗方案调整等方面具有重要价值。因此,GA的简便、快速、低成本、高灵敏和高选择性检测对糖尿病的治疗和病情监测意义重大。本文系统归纳总结了GA的检测方法,重点阐述了各种检测方法的原理及优缺点,对GA检测方法近年来的研究进展进行了评述,最后对其发展趋势进行了展望。Diabetes mellitus,commonly called diabetes,is a group of chronic metabolic diseases characterized by the hyperglycemia over a prolonged period of time.Diabetes mellitus and its complications have become a serious global public health issue.Due to the lack of effective cure means,blood glucose monitoring has become an integral part of the diabetes management.As the product of the nonenzymatic glycation reaction between human serum albumin(HSA)and glucose in the blood,glycated albumin(GA)can effectively reflect the overall blood glucose level in the past two-three weeks.As a result,GA has been demonstrated to be a promising serum marker for the short-term glycemic control assessment,effectiveness evaluation,and therapy adjustment of diabetic patients.Accordingly,the simple,fast,low-cost,and highly sensitive and selective detection method for GA is of great value to diabetes management.In this review,a comprehensive overview of the progress on methods for GA detection was presented,with a focus on the detection principles and their respective advantages and disadvantages.Also,the prospect of the method for GA detection was presented.

关 键 词：糖化白蛋白 糖化血红蛋白 糖尿病 血糖监测 非酶促糖基化 评述 

分 类 号：R587.1[医药卫生—内分泌]