Self-reinforced Calcium Phosphate Cement Inspired by Sea Cucumber Dermis  

作　　者：吴治文 WANG Zihao CAI Zepeng QU Liting 于涛 WU Zhiwen;WANG Zihao;CAI Zepeng;QU Liting;YU Tao(College of Chemistry and Materials Science,Jinan University,Guangzhou 510632,China;Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital),Jinan University,Heyuan 517000,China)

机构地区：[1]College of Chemistry and Materials Science,Jinan University,Guangzhou 510632,China [2]Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital),Jinan University,Heyuan 517000,China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2024年第3期682-688,共7页武汉理工大学学报（材料科学英文版）

基　　金：Supported by the National Natural Science Foundation of China(Nos.31670969,82172440);the Fundamental Research Funds for the Central Universities(Nos.21620417,21621103);the Medical Joint Fund of Jinan University(No.YXJC2022005);the National Key Research and Development Program of China(No.2022YFE0206200);the Funding of Science and Technology Projects in Guangzhou(Nos.202206010158,202201020087)。

摘　　要：A composite bone cement based onα-TCP with self-reinforcing characteristics is prepared by compounding cellulose whiskers and polyvinyl alcohol in different proportions.In this system,we are inspired by the sea cucumber,which can alter the stiffness of their inner dermis reversibly.Through the formation of hydrogen bonds between the hydroxyl groups on the cellulose whiskers and PVA,the bone cement matrix can be strengthened during the curing process of cement.In the process of bone cement blending,there is more water,the hydrogen bond connection is destroyed,so the slurry has better fluidity at this time.As the hydration of the bone cement progresses,the reduction of the water phase leads to the formation of a permeable network structure of hydrogen bond connections between the whiskers.The dual-phase action of PVA and whiskers greatly increases the mechanical strength of the bone cement system(5.5 to 23.8 MPa),while the presence of polyvinyl alcohol improves the toughness of the bone cement system.This work was supposed to explore whether the chemoresponsive materials can be adapted to biomedical materials,for example,bone repair.

关 键 词：bone repair self-reinforce chemoresponsive hydrogen bond 

分 类 号：R318.08[医药卫生—生物医学工程] TQ172.1[医药卫生—基础医学]