阿胶多肽的组成及功能研究进展  

Research Progress on Composition and Function of Colla Corii Asini Polypeptide

作　　者：陈瑛琪 任世利 刘广志 王乐涛 李明 张翠翠 朱明月 史瑞瑞 王超[1] CHEN Ying-qi;REN Shi-li;LIU Guang-zhi;WANG Le-tao;LI Ming;ZHANG Cui-cui;ZHU Ming-yue;SHI Rui-rui;WANG Chao(College of Life Science and Engineering,Jining University,Qufu 273155,China;Shandong Dong'e Runhuitang Ejiao Co.,Ltd,DongE 252200,China;Dong'e County Inspection and Testing Center,DongE 252200,China;Shandong Dong'e Dongyun Ejiao Co.,Ltd,DongE 252200,China)

机构地区：[1]济宁学院生命科学与工程学院,山东曲阜273155 [2]山东东阿润惠堂阿胶有限公司,山东东阿252200 [3]东阿县检验检测中心,山东东阿252200 [4]山东东阿东韵阿胶股份有限公司,山东东阿252200

出　　处：《山东农业大学学报（自然科学版）》2024年第2期288-294,共7页Journal of Shandong Agricultural University：Natural Science Edition

基　　金：山东省重点扶持区域引进急需紧缺人才项目;山东省职业教育教学改革研究项目(2021402);山东省社会科学规划研究项目(22CKRJ01);济宁学院服务黄河国家战略重点专项(2023HHKJ03);济宁学院科研创新团队项目(23KCTD06)。

摘　　要：文章综述了近年来阿胶多肽组成、性质和保健作用等方面取得的研究进展。通过生物信息学研究发现,阿胶主要成分是Ⅰ型胶原蛋白(COLIα1、COLIα2)、Ⅱ型胶原蛋白(COLIIα1)和血清白蛋白(ALB)等大分子量蛋白质。不同研究团队使用生物酶分解阿胶蛋白获得不同长度和种类的小分子量阿胶多肽序列。动物实验表明:阿胶多肽在不同层级的免疫调节中发挥重要作用;阿胶多肽能够促进贫血小鼠外周血白细胞、红细胞和血红蛋白数量的升高;同时,不同阿胶多肽表现的抗氧化能力有显著差异;另外,阿胶多肽在降低血压、改善阿尔兹海默症、抑制肿瘤等方面发挥重要作用。上述结果为今后研究阿胶多肽的产品研发和临床应用提供了重要理论依据。We reviewed the research progress of composition,properties and health function of Colla Corii Asini polypeptide recently.It is found that the main component of Colla Corii Asini is type I collagen(COLIα1,COLIα2),type II collagen(COLIIα1)and high molecular weight proteins such as serum albumin(ALB)through bioinformatics research.Different research teams use biological enzymes to digest Colla Corii Asini protein to obtain small molecular weight polypeptide sequences of different lengths and types.Animal experiments show that Colla Corii Asini polypeptides play an important role in different levels of immune regulation;polypeptide can promote the increase of leukocyte and erythrocyte and hemoglobin in peripheral blood of anemic mice.At the same time,the antioxidant capacity of different Colla Corii Asini polypeptides was significantly different;In addition,polypeptide plays an important role in lowering blood pressure,improving Alzheimer's disease,inhibiting tumor,etc.The above results provide an important theoretical basis for future research on product development and clinical application of Colla Corii Asini polypeptide.

关 键 词：阿胶 阿胶多肽 免疫调节 抗氧化 补血 抗肿瘤 

分 类 号：Q51[生物学—生物化学]