不同类型程序性细胞死亡在苯致血液毒性作用中的研究进展  

Progress of different programmed cell death pathways in benzene induced hematotoxicity

作　　者：秦汝男 刘保峰[1] 李旭东 李培[1] 曾强[1] QIN Ru-nan;LIU Bao-feng;LI Xu-dong;LI Pei;ZENG Qiang(Institute for Occupational Health,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China)

机构地区：[1]天津市疾病预防控制中心职业健康所,天津300011

出　　处：《现代预防医学》2024年第8期1390-1395,1419,共7页Modern Preventive Medicine

基　　金：天津市卫生健康科技项目(TJWJ2023QN088);天津市医学重点建设学科(TJYXZDXK-066B)。

摘　　要：苯具有明确致癌性,可以导致白血病,严重危害涉苯劳动者职业健康,探索苯诱导血液毒性机制对于精准防控苯的健康影响意义重大。随着分子生物学技术不断发展,新近发现多个程序性细胞死亡(PCD)形式,相关研究涉及多个领域,并有研究报道部分PCD与苯诱导血液毒性作用机制有关。本文通过PubMed和CNKI等平台查阅相关文献,简要阐述细胞凋亡、细胞自噬、细胞焦亡和铁死亡等细胞死亡程序的分子机制,讨论已报道的PCD形式在苯诱导血液毒性中的作用及影响,以期为从PCD角度深入研究苯血液毒性作用机制提供新的方向和建议。Benzene has clear carcinogenicity and can lead to leukemia,posing a serious threat to the occupational health of workers with benzene exposure.Exploring the mechanism of benzene induced hematotoxicity is of great significance for precise prevention and control of the health effects of benzene.With the continuous development of molecular biological methods,multiple forms of programmed cell death(PCD)have recently been discovered,and related research involves multiple fields.Some studies have reported that some PCD are related to the mechanism of benzene induced hematotoxicity.This article reviews relevant literature through platforms such as PubMed and CNKI,briefly elaborating on the molecular mechanisms of cell death programs such as apoptosis,autophagy,pyroptosis,and ferroptosis,and discussing the role and impact of reported forms of PCD in benzene induced hematotoxicity,in order to provide new directions and suggestions for in-depth research on the mechanism of benzene hematotoxicity from the perspective of PCD.

关 键 词：苯 程序性细胞死亡 血液毒性 职业健康 

分 类 号：R135[医药卫生—劳动卫生]