成都市锦江区2012—2022年艾滋病抗病毒治疗患者生存情况分析  

Survival conditions of HIV/AIDS patients receiving antiretroviral therapy,Jinjiang district,Chengdu,2012-2022

作　　者：兰慧 庞轶 李旭丹 文偲廙 柯玲[2] 付萍[2] LAN Hui;PANG Yi;LI Xu-dan;WEN Si-yi;KE Ling;FU Ping(Chengdu Jinjang District Center for Disease Control and Prevention,Chengdu,Sichuan 610065,China;不详)

机构地区：[1]成都市锦江区疾病预防控制中心,四川成都610065 [2]中国医学科学院输血研究所

出　　处：《现代预防医学》2024年第8期1518-1523,共6页Modern Preventive Medicine

摘　　要：目的 了解成都市锦江区艾滋病患者在接受抗病毒治疗后的生存情况和影响因素,评估锦江区艾滋病抗病毒治疗效果和优化随访管理模式。方法 利用国家艾滋病综合防治信息系统收集在锦江区2012—2022年开始接受抗病毒治疗者的随访信息,应用寿命表法描述生存情况,采用多因素Cox比例风险回归模型分析研究对象生存时间的影响因素。结果 共2 113例接受治疗者纳入分析,平均年龄(38.65±15.65)岁,平均生存时间132.41月。至随访观察终止时间,死亡71例,治疗第1、3、5、10年的累积生存率分别为97.86%、96.78%、96.43%和95.73%,多因素Cox回归分析显示相对于入组治疗时年龄<30岁组,40~49岁、50~59岁及≥60岁组患者死亡相对危险度分别为4.233(95%CI:1.608~11.139)、3.997(95%CI:1.265~12.623)、19.994(95%CI:7.424~53.846);相对于已婚有配偶者,未婚患者死亡相对危险度为3.359(95%CI:1.495~7.546);相对于确诊至治疗间隔30天者,31~60天与61~90天患者死亡相对危险度分别为2.337(95%CI:1.311~4.165)、3.430(95%CI:1.608~7.319);相对于基线CD4计数<200个/μl者,基线CD4计数200~349个/μl与≥350个/μl组患者死亡相对危险度分别为0.262(95%CI:0.135~0.509)、0.206(95%CI:0.080~0.530);相对于治疗时未出现艾滋病相关症状者,已出现症状者死亡相对危险度为2.088(95%CI:1.051~4.148)。结论 锦江区艾滋病抗病毒治疗效果显著,应在扩大治疗覆盖面的基础上,根据本地区实际情况,制定相应的随访管理措施与干预手段。Objective To investigate the survival situation and influencing factors of patients receiving antiretroviral therapy(ART)in Jinjiang district,Chengdu,and to evaluate the effect of ART and optimize follow-up management mode.Methods The follow-up data of HIV/AIDS patients were collected from the National HHART reporting system during 2012-2022.Life table method was used to describe the survival status,and Cox proportion hazard regression model was used to identify the factors related to survival time.Results A total number of 2113 cases was enrolled,the average age of the study subjects was(38.65±15.65)years old,and the average survival time was 132.41 months.By the time of the follow-up observation was terminated,71 cases died.The accumulated survival rates of 1,3,5 and 10 year after initiating ART were 97.86%,96.78%,96.43%and 95.73%,respectively.The multivariable Cox proportional hazards regression analysis indicated that the risk of death.The HR of 40-49 years,50-59 years,and≥60 years group were 4.233(95%CI:1.608-11.139),3.997(95%CI:1.265-12.623),19.994(95%CI:7.424-53.846)relative to<30 years group,respectively.The HR of unmarried group was 3.359(95%CI:1.495-7.546)relative to married group.The HR of interval time between diagnosis and treatment 31-60 days,61-90 days group were 2.337(95%CI:1.311-4.165),3.430(95%CI:1.608-7.319)relative to≤30 days group.The HR of 200-349 cells/μl and≥350 cells/μl baseline CD4+T cells counts group were 0.262(95%CI:0.135-0.509),0.206(95%CI:0.080-0.530)relative to<200 cells/μl group.The HR of related symptoms before treatment group was 2.088(95%CI:1.051-4.148)relative to no related symptoms before treatment group.Conclusion The effect of patients receiving ART in Jinjiang District is remarkable.ART coverage should be extended,and corresponding follow-up management measures and intervention means should be developed according to the actual situation in Jinjiang District.

关 键 词：艾滋病 抗病毒治疗 生存分析 影响因素 

分 类 号：R512.91[医药卫生—内科学]