双着丝粒染色体自动分析研究进展  

Advances in research on automated dicentric chromosome assay

作　　者：孟倩倩[1] 张忠新[1] 任越[1] 张睿凤 Meng Qianqian;Zhang Zhongxin;Ren Yue;Zhang Ruifeng(Department of Radiology and Environmental Medicine,China Institute for Radiation Protection,Taiyuan 030006,China)

机构地区：[1]中国辐射防护研究院放射医学与环境医学研究所,太原030006

出　　处：《中华放射医学与防护杂志》2024年第4期330-336,共7页Chinese Journal of Radiological Medicine and Protection

摘　　要：双着丝粒染色体分析作为生物剂量估算的"金标准",在大规模核辐射事件中对于快速做出临床决策至关重要。传统人工分析费时费力,通量低,且对人员的技术要求高,难以满足大规模核事故情况下大量人员剂量估算的要求。近年来,针对大规模辐射事件下受照人员高通量、快速、准确的剂量估算需求,研究者们开发了多种策略。本文介绍了双着丝粒染色体自动分析检测方法的研究进展,为国内同行开展基于双着丝粒染色体指标估算生物剂量研究提供参考。Dicentric chromosome assay(DCA),the"golden on standard"for biodosimetry,plays a critical in making rapid clinical decisions in mass casualty nuclear incidents.However,traditional manual analysis is hard-pressed to meet the biodosimetry needs in nuclear mass casualty incidents due to its high requirements for time,labor,throughput,and operation techniques.In recent years,several novel strategies have emerged to fill the gap in high-throughput,rapid,and accurate dosimetry for exposed personnel in nuclear mass casualty incidents.This study introduces the advances in research on automated dicentric chromosome assay,providing a reference for domestic peers on biodosimetry studies based on dicentric chromosomes.

关 键 词：双着丝粒染色体 自动分析 生物剂量估算 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]