枸地氯雷他定致皮疹和血管神经性水肿  

Desloratadine citrate-induced rash and angioneurotic edema

作　　者：郭宁宁[1] 房高飞 Guo Ningning;Fang Gaofei(Department of Clinical Medicine,Yantai Laiyang Central Hospital,Shandong Province,Laiyang 265200,China;Department of Pharmacy,Laixi People’s Hospital,Shandong Province,Laixi 266600,China)

机构地区：[1]烟台市莱阳中心医院临床药学科,莱阳265200 [2]莱西市人民医院药剂科,莱西266600

出　　处：《药物不良反应杂志》2024年第4期244-245,共2页Adverse Drug Reactions Journal

摘　　要：1例64岁女性患者因膝关节疼痛外敷土方药物后局部肿胀、水疱给予抗菌、止痛等治疗,7 d后出现局部皮肤红肿和散在皮疹,给予葡萄糖酸钙静脉滴注、枸地氯雷他定口服等抗过敏治疗。第2天患者全身出现风团样皮疹,继续静脉应用抗过敏药物,当日患者皮肤症状有所缓解。再次口服枸地氯雷他定1.5 h后,患者全身皮疹加重,次日出现血管神经性水肿。停用枸地氯雷他定,继续给予地塞米松、异丙嗪及其他对症处理,4 d后患者症状完全消失。A 64-year-old female patient received treatments such as antibacterial,analgesic,etc.due to local swelling and blisters caused by application of domestically made drug for external use for knee joint pain.After 7 days,local skin redness and swelling appeared,with scattered rashes.Anti-allergic treatments including intravenous infusion of calcium gluconate and oral desloratadine cirate were given.On the second day,the patient developed a wheal like rash all over her body,and intravenous infusion of anti-allergic drugs were continued.On the same day,the patient’s skin symptoms were improved.The patient’s systemic rash worsened again after 1.5 hours of reapplication of desloratadine cirate,and the next day,angioneurotic edema appeared.Desloratadine cirate was stopped,dexamethasone,promethazine,and other symptomatic treatments were continued.Four days later,the patient’s symptoms completely disappeared.

关 键 词：组胺拮抗剂 皮疹 血管神经性水肿 枸地氯雷他定 

分 类 号：R969.3[医药卫生—药理学]