氨氯地平贝那普利片对老年高血压合并冠心病患者血压及心脏功能的影响  

Effect of amlodipine/benazepril tablets on blood pressure and cardiac function in older adults with hypertension complicated by coronary heart disease

作　　者：洪飞 李轩 汪磊 Hong Fei;Li Xuan;Wang Lei(Ward 6 of Department of Cardiology,Liaoning Jinqiu Hospital,Shenyang 110000,Liaoning Province,China;Ward 2 of Department of Special Consultation,Liaoning Jinqiu Hospital,Shenyang 110000,Liaoning Province,China)

机构地区：[1]辽宁省金秋医院心血管内科六病房,沈阳110000 [2]辽宁省金秋医院特诊二病房,沈阳110000

出　　处：《中国基层医药》2024年第4期543-548,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察氨氯地平贝那普利片对老年高血压合并冠心病患者的血压达标情况及心功能改善效果。方法选取辽宁省金秋医院2020年2月至2022年2月收治的老年高血压合并冠心病患者98例为研究对象,采用随机对照研究方法,以随机抽签法分为观察组和对照组各49例,对照组给予氨氯地平片治疗,观察组给予氨氯地平贝那普利片治疗,治疗3个月,比较两组患者的血压情况及心脏功能改善情况。结果治疗前,两组舒张压(DBP)、收缩压(SBP)、心功能指标、炎性因子水平比较,差异均无统计学意义(均P>0.05)。治疗后,观察组DBP、SBP[(88.74±4.26)mmHg、(125.47±6.23)mmHg](1 mmHg=0.133 kPa)均低于对照组[(95.71±4.55)mmHg、(134.28±6.10)mmHg](t=7.07、7.82,均P<0.001);治疗后,观察组内皮素(ET-1)低于对照组,一氧化氮(NO)水平高于对照组,差异均有统计学意义(t=5.02、4.96,均P<0.05);观察组左心室收缩末期内径(44.04±3.26)mm,低于对照组的(48.58±3.19)mm(t=6.96,P<0.001),左心室舒张末期内径(52.07±4.11)mm,低于对照组的(60.12±4.30)mm(t=9.47,P<0.001),左心室射血分数(54.08±3.06)%,高于对照组的(47.50±3.22)%(t=10.36,P<0.001);观察组肿瘤坏死因子α、白细胞介素6、C反应蛋白水平均低于对照组(t=5.53、12.48、13.45,均P<0.001)。结论氨氯地平贝那普利治疗老年高血压并冠心病患者,可促使其心功能与血管内皮功能的改善,有利于血压的控制,减轻机体的炎性反应。Objective To investigate the effect of amlodipine/benazepril tablets on blood pressure control and cardiac function improvement in older adult patients with hypertension complicated by coronary heart disease.Methods A randomized controlled clinical study was conducted on 98 older adult patients with hypertension complicated by coronary heart disease who were diagnosed and treated at Liaoning Jinqiu Hospital between February 2020 and February 2022.The patients were randomly divided into an observation group and a control group,with 49 patients in each group using a random lottery method.The control group was treated with amlodipine tablets,while the observation group was treated with amlodipine/benazepril tablets for 3 months.Blood pressure levels and cardiac function improvement were compared between the two groups.Results Prior to treatment,there were no statistically significant differences in diastolic blood pressure,systolic blood pressure,cardiac function indices,and inflammatory factor levels between the two groups(all P>0.05).After treatment,the observation group exhibited lower levels of diastolic blood pressure and systolic blood pressure[(88.74±4.26)mmHg,(125.47±6.23)mmHg,1 mmHg=0.133 kPa]compared with the control group[(95.71±4.55)mmHg,(134.28±6.10)mmHg,t=7.07,7.82,both P<0.001].After treatment,the observation group showed lower levels of endothelin 1 and higher levels of nitric oxide compared with the control group(t=5.02,4.96,both P<0.05).After treatment,the observation group demonstrated lower left ventricular end-systolic diameters[(44.04±3.26)mm vs.(48.58±3.19)mm,t=6.96,P<0.001],lower left ventricular end-diastolic diameters[(52.07±4.11)mm vs.(60.12±4.30)mm,t=9.47,P<0.001],and higher levels of left ventricular ejection fraction[(54.08±3.06)%vs.(47.50±3.22)%,t=10.36,P<0.001]compared with the control group.The levels of tumor necrosis factor-alpha,interleukin-6,and C-reactive protein in the observation group were significantly lower than those in the control group(t=5.53,12.48,13.45,all P<

关 键 词：高血压 冠状动脉疾病 抗高血压药 内皮缩血管肽类 肿瘤坏死因子α C反应蛋白 白细胞介素6 老年人 氨氯地平贝那普利片 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]