消囊调经汤联合达英-35对多囊卵巢综合征患者性激素、脂代谢和卵巢间质血流的影响  

Effects of Xiaonang Tiaojing Decoction Combined with Diane-35 on Sex Hormones,Lipid Metabolism and Ovarian Stromal Blood Flow in Patients with Polycystic Ovary Syndrome

作　　者：李曌洋 李潇[1] 吴梦瑶 余晓依 周艳艳 LIZhao-yang;LI Xiao;WU Meng-yao;YU Xiao-yi;ZHOU Yan-yan(The Second Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,450053,China;Department of Traditional Chinese Medicine Gynaecology,Xinzheng Public People's Hospital,Xinzheng,Henan,451150,China;Department of Gynecology(Henan Provincial Hospital of Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine),Zhengzhou,Henan,450053,China)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450053 [2]新郑市公立人民医院中医妇科,河南新郑451150 [3]河南省中医院(河南中医药大学第二附属医院)妇科,河南郑州450053

出　　处：《现代生物医学进展》2024年第5期915-918,共4页Progress in Modern Biomedicine

基　　金：河南省科技攻关项目(212102311138)。

摘　　要：目的:观察消囊调经汤联合达英-35对多囊卵巢综合征(PCOS)患者性激素、脂代谢和卵巢间质血流的影响。方法:选择2020年7月~2022年12月期间河南省中医院收治的PCOS患者117例。按照随机数字表法分为对照组(达英-35,58例)和研究组(消囊调经汤联合达英-35,59例)。对比两组性激素指标[促黄体生成素(LH)、雌二醇(E_(2))、促卵泡生成素(FSH)、睾酮(T)]、中医证候积分、脂代谢[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)]和卵巢间质血流情况[子宫动脉搏动指数(PI)、子宫动脉阻力指数(RI)]。结果:研究组治疗后主症积分、次症积分、总积分低于对照组(P<0.05)。研究组治疗后LH、E_(2)、FSH、T低于对照组(P<0.05)。研究组治疗后HDL-C高于对照组;TC、TG、LDL-C低于对照组(P<0.05)。研究组治疗后PI、RI低于对照组(P<0.05)。结论:消囊调经汤联合达英-35治疗PCOS患者,可改善患者的临床症状,调节机体性激素、脂代谢和卵巢间质血流,疗效较好。Objective:To observe the effects of xiaonang tiaojing decoction combined with diane-35 on sex hormones,lipid metabolism and ovarian stromal blood flow in patients with polycystic ovary syndrome(PCOS).Methods:117 patients with PCOS who were admitted to Henan Provincial Hospital of Traditional Chinese Medicine from July 2020 to December 2022 were selected.Patients were divided into control group(diane-35,58 cases)and study group(xiaonang tiaojing decoction combined with diane-35,59 cases)according to the random number table method.The sex hormone indexes[luteinizing hormone(LH),estradiol(E_(2)),follicle stimulating hormone(FSH),testosterone(T)],chinese medicine syndrome scores,lipid metabolism[high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC)]and ovarian stromal blood flow[uterine artery pulsation index(PI),uterine artery resistance index(RI)]were compared between two groups.Results:The main symptom score,secondary symptom score and total score in study group were lower than those in control group after treatment(P<0.05).LH,E_(2),FSH and T in study group were lower than those in control group after treatment(P<0.05).HDL-C in study group was higher than that in control group;TC,TG and LDL-C were lower than those in control group after treatment(P<0.05).PI and RI in study group were lower than those in control group after treatment(P<0.05).Conclusion:Xiaonang tiaojing decoction combined with diane-35 in the treatment of PCOS patients,which can improve the clinical symptoms of patients,regulate the body's sex hormones,lipid metabolism and ovarian stromal blood flow,and the curative effect is good.

关 键 词：消囊调经汤 达英-35 多囊卵巢综合征 性激素 脂代谢 卵巢间质血流 

分 类 号：R711.75[医药卫生—妇产科学] R243[医药卫生—临床医学]