血清CyPA、sCLU、HO-1与新生儿窒息复苏后发生脑损伤的关系研究  

Study on the Relationship between Serum CyPA,sCLU,HO-1 and Brain Injury after Neonatal Asphyxia Resuscitation

作　　者：向垚林 吴素英 刘兆敏 方超策 周玉 彭芬 XIANG Yao-lin;WU Su-ying;LIU Zhao-min;FANG Chao-ce;ZHOU Yu;PENG Fen(Department of Neonatology,Minda Hospital Affiliated to Hubei Minzu University,Enshi,Hubei,445000,China)

机构地区：[1]湖北民族大学附属民大医院新生儿科,湖北恩施445000

出　　处：《现代生物医学进展》2024年第6期1150-1154,1134,共6页Progress in Modern Biomedicine

基　　金：湖北省卫生健康委科研立项项目(WJ2019F148)。

摘　　要：目的:探讨血清亲环素A(CyPA)、丛生蛋白(sCLU)、血红素氧化酶-1(HO-1)与新生儿窒息复苏后发生脑损伤的关系。方法:选择2020年6月至2023年3月湖北民族大学附属民大医院收治的172例窒息新生儿,根据复苏后是否发生脑损伤分为脑损伤组(80例)和无脑损伤组(92例),复苏治疗前检测并对比两组血清CyPA、sCLU、HO-1水平。多因素Logistic回归分析新生儿窒息复苏后发生脑损伤的影响因素,受试者工作特征(ROC)曲线分析血清CyPA、sCLU、HO-1预测新生儿窒息复苏后发生脑损伤的价值。结果:脑损伤组血清CyPA、sCLU、HO-1水平高于无脑损伤组(P<0.05)。胎盘早剥、母体妊娠高血压疾病、重度窒息、高水平CyPA、高水平sCLU、高水平HO-1是新生儿窒息复苏后发生脑损伤的危险因素(P<0.05)。血清CyPA、sCLU、HO-1预测新生儿窒息复苏后发生脑损伤的曲线下面积为0.797、0.832、0.779,联合预测的曲线下面积为0.941,高于各指标单独预测。结论:新生儿窒息复苏后发生脑损伤的危险因素包括胎盘早剥、母体妊娠高血压疾病、重度窒息、CyPA升高、sCLU升高、HO-1升高,联合检测血清CyPA、sCLU和HO-1对新生儿窒息复苏后发生脑损伤具有较高的预测价值。Objective:To investigate the relationship between serum cyclophilin A(CyPA),clusterin(sCLU),heme oxygenase-1(HO-1)and brain injury after neonatal asphyxia resuscitation.Methods:172 asphyxiated neonates who were admitted to Minda Hospital Affiliated to Hubei Minzu University from June 2020 to March 2023 were selected,patients were divided into brain injury group(80 cases)and non-brain injury group(92 cases)according to whether brain injury occurred after resuscitation,the levels of serum CyPA,sCLU and HO-1 were detected and compared between two groups before resuscitation.The influencing factors of brain injury after neonatal asphyxia resuscitation were analyzed by multivariate Logistic regression,the value of serum CyPA,sCLU and HO-1 in predicting brain injury after neonatal asphyxia resuscitation were analyzed by receiver operating characteristic(ROC)curve.Results:The levels of serum CyPA,sCLU and HO-1 in brain injury group were higher than those in non-brain injury group(P<0.05).Placental abruption,maternal pregnancy-induced hypertension,severe asphyxia,high level of CyPA,high level of sCLU and high level of HO-1 were risk factors for brain injury after neonatal asphyxia resuscitation(P<0.05).The area under the curve of serum CyPA,sCLU and HO-1 in predicting brain injury after neonatal asphyxia resuscitation was 0.797,0.832 and 0.779 respectively.The area under the curve of combined prediction was 0.941,which was higher than that of each index alone.Conclusion:The risk factors for brain injury after neonatal asphyxia resuscitation include placental abruption,maternal pregnancy-induced hypertension,severe asphyxia,increased CyPA,increased sCLU,and increased HO-1,combine detection of serum CyPA,sCLU and HO-1 has a high predictive value for brain injury after neonatal asphyxia resuscitation.

关 键 词：新生儿窒息 脑损伤 CYPA sCLU HO-1 预测价值 

分 类 号：R722[医药卫生—儿科]