影响结核性胸腔积液并发胸膜增厚的非条件Logistic回归分析  

Influence of tuberculous pleural effusion complicated with pleural thickening by unconditioned Logistic regression analysis

作　　者：梁小朋[1] 胡锦兴[1] 韩建芳[1] 蔡智群[1] 吴碧彤[1] LIANG Xiaopeng;HU Jinxing;HAN Jianfang;CAI Zhiqun;WU Bitong(Guangzhou Chest Hospital/State Key Laboratory of Tuberculosis and Respiratory Diseases/Institute of Tuberculosis Control,Guangzhou Medical University,Guangzhou,Guangdong,510095,China)

机构地区：[1]广州市胸科医院/呼吸疾病国家重点实验室/广州医科大学结核病防治研究所,广东广州510095

出　　处：《当代医学》2024年第3期103-106,共4页Contemporary Medicine

基　　金：广东市科技计划项目(201904010071)。

摘　　要：目的探讨影响结核性胸腔积液并发胸膜增厚的相关危险因素。方法回顾性分析2019年1月至2021年3月广州市胸科医院呼吸内科收治的123例结核性胸腔积液患者的临床资料,统计患者胸膜增厚情况,采用单因素及非条件Logistic回归法分析患者胸膜增厚的影响因素。结果胸膜未增厚与胸膜增厚患者性别、年龄、肺结核、胸水分布、用力肺活量(FVC)、第1秒用力呼气容积(FVE1)/FVC、胸水腺苷脱氨酶(ADA)、血清ADA、胸水白细胞、胸水淋巴细胞、胸水中性粒细胞和淋巴细胞比例比较差异无统计学意义;胸膜未增厚与胸膜增厚患者胸水量、胸水吸收时间、FVE1、胸水乳酸脱氢酶(LDH)、血清LDH、胸水蛋白、血清蛋白比较差异有统计学意义(P<0.05)。Logistic回归分析结果显示,胸水量(中大量)、FVE1、胸水LDH、血清LDH、胸水蛋白及血清蛋白是胸膜增厚发生的危险因素(P<0.05)。结论结核性胸腔积液并发胸膜增厚是多因素作用的结果,胸水量、FVE1、胸水吸收时间、胸水LDH、血清LDH、胸水蛋白和血清蛋白与胸膜增厚的发生密切相关,建议临床予以密切监测并积极采取针对性干预措施。Objective To investigate the risk factors of tuberculous pleural effusion complicated with pleural thickening.Methods The clinical data of 123 patients with tuberculous pleural effusion admitted to the respiratory medicine department of Guangzhou Chest Hospital from January 2019 to March 2021 were retrospectively analyzed.The pleural thickening of the patients was statistically analyzed,and the influencing factors of pleural thickening were analyzed by univariate and unconditional Logistic regression methods.Results There were no significant differences in gen-der,age,pulmonary tuberculosis,pleural fluid distribution,forced vital capacity(FVC),forced expiratory volume at the forced expiratory volume in one second(FVE1)/FVC,adenosine deaminase(ADA),serum ADA,pleural leukocyte,pleural fluid lymphocyte,pleural neutrocyte and lymphocyte ratio between patients with no pleural thickening and pleural thickening.There were significant differences in pleural water volume,pleural fluid ab-sorption time,FVE1,pleural fluidlactate dehydrogenase(LDH),serum LDH,pleural fluid protein and serum protein between patients with no pleural thickening and patients with pleural thickening(P<0.05).Logistic regression analysis showed that pleural volume,FVE1,pleural fluid LDH,serum LDH,pleural fluid protein and serum protein were risk factors for pleural thickening(P<0.05).Conclusion Tuberculous pleural effusion complicat-ed with pleural thickening is the result of multiple factors,pleural water volume,FVE1,pleural effusion absorption time,pleural effusion LDH,serum LDH,pleural effusion protein and serum protein are closely related to the occurrence of pleural thickening,and it is recommended to closely monitor and actively take targeted intervention measures.

关 键 词：结核性胸腔积液 胸膜增厚 非条件LOGISTIC回归分析 危险因素 

分 类 号：R655.2[医药卫生—外科学]