35例胺碘酮注射液致过敏性休克病例报告分析  

Analysis of 35 Cases of Allergic Shock Induced by Amiodarone Injection

作　　者：郗玉玲[1,2,3] 李大通 王鹏伟 平贯芳 邓智建 XI Yu-ling;LI Da-tong;WANG Peng-wei;PING Guan-fang;DENG Zhi-jian(Department of Clinical Pharmacy,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China;Clinical Pharmacy,Henan Province Key Subjects of Medicine,Weihui 453100,China;Xinxiang Key Laboratory for Individualized Drug Use Research for Immune Diseases,Weihui 453100,China;Xinxiang Hualan Biological Vaccine Inc.,Xinxiang 453000,China)

机构地区：[1]新乡医学院第一附属医院临床药学学部,卫辉453100 [2]河南省医学重点学科,药学其他学科(临床药学),卫辉453100 [3]新乡市免疫性疾病个体化用药研究重点实验室,卫辉453100 [4]新乡华兰生物疫苗股份有限公司,新乡453000

出　　处：《中国合理用药探索》2024年第4期18-23,共6页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关联合共建项目(LHGJ20210525)。

摘　　要：目的:探讨胺碘酮注射液致过敏性休克的用药特点及影响因素,确保安全用药。方法:检索中英文数据库中收录的胺碘酮注射液致过敏性休克的病例报告并进行统计分析。结果:共检索到28篇病例报告,共涉及35例患者。其中,女性患者多于男性;60岁及以上患者18例;29例(82.86%)患者的过敏性休克发生在用药后5min或用药量5ml以内;主要累及系统/器官为呼吸系统疾病、皮肤及皮肤附件疾病、心血管疾病、全身整体疾病等;临床表现以血压骤降、胸闷/气短为主。结论:医护人员应加强患者用药初期用药监护,预防或减少致死性事件的发生。Objective:To explore the medication characteristics and influencing factors of allergic shock induced by amiodarone injection,and to ensure safe medication.Methods:The case reports of allergic shock caused by amiodarone injection were statistically analyzed by searching Chinese and English databases.Results:A total of 28 case reports were retrieved,with a total of 35 cases.Women were higher than men,18 cases were 60 years old and above,29 cases(82.86%)of patients with allergic shock occurred within 5 min or 5 ml of medication.The allergic shock mainly involves respiratory system diseases,skin and skin adnexal diseases,angiocardiopathy,systemic diseases,etc.with manifestations such as a sudden drop in blood pressure and chest tightness/shortness of breath.Conclusion:Healthcare professionals should strengthen early medication monitoring of patients to prevent and reduce the occurrence of fatal events.

关 键 词：胺碘酮注射液 过敏性休克 合理用药 安全性 分析 

分 类 号：R969.3[医药卫生—药理学]