普米克令舒配合有氧运动对支气管哮喘康复效果的影响研究  

Study on the Effect of Pulmicort Respules Combined with Aerobic Exercise on the Rehabilitation of Bronchial Asthma

作　　者：潘文文 王楠 PAN Wenwen;WANG Nan(Zhengzhou 460 Hospital,Zhengzhou Henan 450000,China.)

机构地区：[1]郑州四六〇医院,河南郑州450000

出　　处：《药品评价》2024年第1期82-86,共5页Drug Evaluation

基　　金：河南省医学科技攻关项目(LHGJ202001172)。

摘　　要：目的观察普米克令舒配合有氧运动对改善支气管哮喘患者康复效果的影响。方法本文为前瞻性研究,选择郑州四六〇医院2020年10月至2023年3月期间收治的100例支气管哮喘患者为研究对象采用计算机随机数字表法将其分为常规组和联合组,各50例。常规组在常规药物治疗基础上配合有氧运动,联合组在常规药物治疗基础上加用普米克令舒配合有氧运动,比较两组的症状缓解时间,治疗前后的炎症反应、肺功能改善情况、哮喘控制测试(ACT)评分改善情况及治疗安全性。结果联合组的咳嗽消失时间、呼吸困难缓解时间、肺部啰音消失时间、喘息消失时间及住院时间分别为(6.44±2.12)d、(1.82±0.46)d、(3.36±0.77)d、(2.51±0.46)d、(14.49±3.46)d,均低于常规组[(9.77±3.42)d、(2.35±0.26)d、(4.49±1.26)d、(3.23±0.46)d、(17.72±5.36)d];联合组治疗后的Toll样受体(TLR)2、TLR4表达量分别为(1.35±0.41)、(0.85±0.21),均低于常规组[(1.77±0.45)、(1.18±0.36)];联合组治疗30 d后的第一秒用力呼气容积百分比(FEV1)、用力肺活量(FVC)、每分钟最大通气量(MVV)分别为(58.65±10.27)%、(2.75±0.36)L、(68.82±10.31)L/min,均高于常规组[(52.11±10.44)%、(2.21±0.25)L、(62.44±10.63)L/min];联合组治疗7 d后、14 d后、30 d后的ACT评分分别为(17.23±4.49)分、(21.77±5.42)分、(26.33±5.49)分,均高于常规组[(14.33±3.45)分、(18.28±5.16)分、(23.19±5.25)分];联合组药物不良反应发生率8.00%(4/50)低于24.00%(12/50),差异具有统计学意义(P<0.05)。结论普米克令舒配合有氧运动能加快支气管哮喘患者的康复进程,对改善患者气道炎症、肺功能,控制哮喘症状、增强康复效果,提升治疗安全性均有积极意义。Objective Observing the effect of combination of pulmicort respules and aerobic exercise on improving the rehabilitation effect of patients with bronchial asthma.Methods This article was a prospective study,selecting 100 patients with bronchial asthma admitted to Zhengzhou 460 Hospital from October 2020 to March 2023 as the research subjects.They were randomLy divided into a conventional group and a combination group using a computer random number table method,with 50 cases in each group.The conventional group was treated with conventional medication combined with aerobic exercise,while the combination group was treated with adjuvant therapy of pulmicort respules on based of conventional group.The symptom relief time,inflammation response,improvement of lung function before and after treatment,improvement of asthma control test(ACT)score,and treatment safety were compared between the two groups.Results The cough disappearance time,dyspnea relief time,lung rale disappearance time,wheezing disappearance time,and hospitalization time of the combination group were(6.44±2.12)d,(1.82±0.46)d,(3.36±0.77)d,(2.51±0.46)d,and(14.49±3.46)d,lower than the conventional group[(9.77±3.42)d,(2.35±0.26)d,(4.49±1.26)d,(3.23±0.46)d,and(17.72±5.36)d];under different treatment regimens,the expression levels of Toll like receptor 2(TLR2)and TLR4 in the combination group after treatment were(1.35±0.41)and(0.85±0.21),lower than the conventional group[(1.77±0.45)and(1.18±0.36)];the first second forced expiratory volume percentage(FEV1),forced vital capacity(FVC),and maximum ventilation volume per minute(MVV)of the combination group after 30 days of treatment were(58.65±10.27)%,(2.75±0.36)L,and(68.82±10.31)L/min,higher than the conventional group[(52.11±10.44)%,(2.21±0.25)L,and(62.44±10.63)L/min];the ACT scores of the combined group after 7 days,14 days,and 30 days of treatment were(17.23±4.49)points,(21.77±5.42)points,and(26.33±5.49)points,higher than the conventional group[(14.33±3.45)points,(18.28±5.16)points,and

关 键 词：支气管哮喘 普米克令舒 气道炎症 肺功能 哮喘控制测试 

分 类 号：R562.25[医药卫生—呼吸系统]