克唑替尼的合成工艺研究进展  

Research progress on the synthetic technology of Crizotinib

作　　者：杨贵严 沈原源 张莹 施怡 何泉莹 林睿 王连霞 滕明瑜[1] Yang Guiyan;Shen Yuanyuan;Zhang Ying;Shi Yi;He Quanying;Lin Rui;Wang Lianxia;Teng Mingyu(Faculty of Chemistry&Chemical Engineering,Yunnan Normal University,Kunming 650500,China;Library and Information Center,Yunnan Normal University,Kunming 650500,China;Chongqing Southwest Aluminum Hospital,Chongqing 401326,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500 [2]云南师范大学图文信息中心,云南昆明650500 [3]重庆西南铝医院,重庆401326

出　　处：《云南化工》2024年第4期1-7,共7页Yunnan Chemical Technology

摘　　要：主要介绍了国内外克唑替尼(Crizotinib)及其关键手性中间体(S)-1-(2,6-二氯-3-氟苯基)乙醇的相关合成工艺路线,对其进行分析后指出了存在的问题及优点,最终总结出了较好的合成工艺路线,为相关研究人员快速了解克唑替尼其关键手性中间体的合成工艺提供参考。In this paper,the synthetic processes of Crizotinib and its key chiral intermediate(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol were introduced,and the problems and advantages of each process were pointed out.Finally,the synthetic process was summarized.It provides references for relevant readers to quickly understand the synthesis process of crizotinib and its key chiral intermediates.

关 键 词：克唑替尼 关键手性中间体 非小细胞肺癌 化学合成 

分 类 号：TQ463.4[化学工程—制药化工]