国内ICU多重耐药菌感染患者的疾病负担Meta分析  

Meta-analysis of disease burden in ICU patients infected with multidrug resistant bacteria in China

作　　者：宋红升 王忠礼 王宇萍[1] Song Hongsheng;Wang Zhongli;Wang Yuping(Chinese Academy of Medical Sciences&Peking Union Medical College,School of Population Medicine And Public Health,Beijing 100730)

机构地区：[1]中国医学科学院北京协和医学院群医学及公共卫生学院,北京100730

出　　处：《中国抗生素杂志》2024年第4期427-437,共11页Chinese Journal of Antibiotics

基　　金：中国医学科学院医学与健康科技创新工程(No.2021-I2M-1-045)。

摘　　要：目的了解国内ICU多重耐药菌感染患者的疾病负担,为多重耐药的深入研究提供参考。方法2022年10月系统检索中文数据库中国知网、万方、维普和中国生物医学,以及英文数据库PubMed,Embase,Web of Science和The Cochrane Library中收录的有关中国ICU多重耐药菌感染患者的疾病负担的研究。由2位研究者独立对文献进行筛选以及提取数据后,采用Review Manager 5.4软件进行Meta分析。结果共纳入中、英文文献18篇。国内ICU患者发生多重耐药菌感染的死亡风险是未发生多重耐药患者的1.54~3.00倍,多重耐药菌感染患者的平均住院时间比未发生多重耐药菌感染的患者延长4.11~20.17 d,住院费用的研究均显示了国内ICU患者发生多重耐药菌感染会增加住院费用。结论国内ICU患者发生多重耐药菌感染会增加死亡风险以及经济负担。但纳入文献均为回顾性研究,且以单中心研究为主,因此对待研究结果需谨慎。Objective To understand the disease burden of patients with multidrug resistance bacteria in the ICU in China and to provide a reference for further research on multidrug resistance.Methods Published studies on the disease burden of patients with multidrug resistance bacteria in the ICU in China were collected from the Chinese databases,which contained CNKI,Wanfang,VIP and SinoMed,and the English databases,which covered PubMed,Embase,Web of Science and The Cochrane Library,in October 2022.Two reviewers independently screened literature and extracted data.Then Meta-analysis was performed using Review Manager 5.4 software.Results A total of 18 works of Chinese and English literature were included.The risk of death in ICU patients in China with multidrug resistance bacterial infections was 1.54~3.00 times that in patients without multidrug resistance bacterial infections,and the average length of stay in patients with multidrug resistance bacterial infections was 4.11~20.17 days longer than that in patients without multidrug resistance bacterial infections.Studies on hospitalization costs had shown that ICU patients in China with multidrug resistance bacterial infections would increase hospitalization costs.Conclusion Multidrug resistance bacterial infections in ICU patients in China may increase the risk of death and economic burden.However,all of the studies were retrospective studies and single-center studies were mainly conducted,so the results should be treated with caution.

关 键 词：ICU 多重耐药菌 医院感染 疾病负担 META分析 

分 类 号：R978.1[医药卫生—药品]