Pushing the frontiers: Chip-based detection based on micro-and nano-structures  

作　　者：Meihui Liu Xinyuan Zhou Xiao Li Zhenjie Xue Tie Wang 

机构地区：[1]Tianjin Key Laboratory of Life and Health Detection,Life and Health Intelligent Research Institute,Tianjin University of Technology,Tianjin 300384,China

出　　处：《Chinese Chemical Letters》2024年第4期86-98,共13页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No.21925405)。

摘　　要：Changes in trace substances in human metabolites, which are related to disease processes and health status, can serve as chemical markers for disease diagnosis and symptom monitoring. Real-time online detection is an inevitable trend for the future of health monitoring, and the construction of chips for detection faces major challenges. The response of sensors often fails to meet the requirements for chipbased detection of trace substances due to the low efficiency of interfacial heterogeneous reactions, necessitating a rational design approach for micro-and nano-structures to improve sensor performance with respect to sensitivity and detection limits. This review focuses on the influence of micro-and nanostructures that used in chip on sensing. Firstly, this review categorizes sensors into chemiresistors, electrochemical sensors, fluorescence sensors, and surface enhanced Raman scattering(SERS) sensors based on their sensing principle, which have significant applications in disease diagnosis. Subsequently, commencing from the application requirements in the field of sensing, this review focuses on the different structures of nanoparticle(NP) assemblies, including wire, layered, core-shell, hollow, concave and deformable structures. These structures change in the size, shape, and morphology of conventional structures to achieve characteristics such as ordered alignment, high specific surface area, space limitation,vertical diffusion, and swaying behavior with fluid, thereby addressing issues such as poor signal transmission efficiency, inadequate adsorption and capture capacity, and slow mass transfer speed during sensing. Finally, the design direction of micro-and nano-structures, and possible obstacles and solutions to promote chip-based detection have been discussed. It is hope that this article will inspire the exploration of interface micro-and nano-structures modulated sensing methods.

关 键 词：Chip-based detection Micro-and nano-structures Real-time online detection Sensing Health monitoring 

分 类 号：R318[医药卫生—生物医学工程] TN407[医药卫生—基础医学]